Tatsch K, Knesewitsch P, Matuschke A, Wainryb H J, Goebel F D, Kirsch C M
Nuklearmedizinische Abteilung der Radiologischen Klinik, Universität München, FRG.
Nucl Med Commun. 1990 Sep;11(9):649-55. doi: 10.1097/00006231-199009000-00008.
This study was designed to evaluate the role of 67Ga-scintigraphy in AIDS-related intestinal infections. Seventeen out of twenty-five HIV-positive patients (68%) primarily investigated with 67Ga-scans to screen for opportunistic pneumonia presented pathologic abdominal 67Ga-uptake which was, in most cases, due to proven opportunistic intestinal infection (cytomegalovirus, atypical mycobacteria, cryptosporidiosis etc.). The correlation of abdominal with pulmonary findings has shown that AIDS-related intestinal infections and opportunistic pneumonia may occur concomitantly in the majority cases (11/17). In 6/17 patients positive abdominal findings were observed without opportunistic pneumonia at the same time. Gallium imaging of the abdomen has shown to identify successfully the most common extrapulmonary sites of HIV-related infections. Thus, abdominal imaging or whole body scintigraphy should be a mandatory part of each 67Ga-scan in patients with HIV infection, even if it was primarily performed to screen for opportunistic pneumonia only. Knowledge of multilocular opportunistic infections, usually caused by different pathogens, is clinically important for further diagnostic and therapeutic management.
本研究旨在评估67镓闪烁扫描在艾滋病相关肠道感染中的作用。25例主要接受67镓扫描以筛查机会性肺炎的HIV阳性患者中，有17例（68%）出现腹部67镓摄取异常，在大多数情况下，这是由于已证实的机会性肠道感染（巨细胞病毒、非典型分枝杆菌、隐孢子虫病等）所致。腹部与肺部检查结果的相关性表明，在大多数病例（11/17）中，艾滋病相关肠道感染和机会性肺炎可能同时发生。在6/17例患者中，观察到腹部检查结果阳性，但同时并无机会性肺炎。腹部镓显像已成功显示出HIV相关感染最常见的肺外部位。因此，即使腹部显像或全身闪烁扫描最初仅用于筛查机会性肺炎，对于HIV感染患者，它也应成为每次67镓扫描的必要组成部分。了解通常由不同病原体引起的多部位机会性感染，对于进一步的诊断和治疗管理具有重要临床意义。
