Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Ups J Med Sci. 2012 May;117(2):166-77. doi: 10.3109/03009734.2012.659293. Epub 2012 Feb 21.
Multiple myeloma (MM) is a B cell malignancy characterized by the expansion of clonal plasmablast/plasma cells within the bone-marrow. It is well established that the bone-marrow microenvironment has a pivotal role in providing critical cytokines and cell-cell interactions to support the growth and survival of the MM tumor clone. The pathogenesis of MM is, however, only fragmentarily understood. Detailed genomic analysis reveals a heterogeneous and complex pattern of structural and numerical chromosomal aberrations. In this review we will discuss some of the recent results on the functional role and potential clinical use of the IGF-1R, one of the major mediators of growth and survival for MM. We will also describe some of our results on epigenetic gene silencing in MM, as it may indeed constitute a novel basis for the understanding of tumor initiation and maintenance in MM and thus may change the current view on treatment strategies for MM.
多发性骨髓瘤（MM）是一种 B 细胞恶性肿瘤，其特征是克隆性浆母细胞/浆细胞在骨髓内扩增。现已证实，骨髓微环境在提供关键细胞因子和细胞-细胞相互作用以支持 MM 肿瘤克隆的生长和存活方面起着关键作用。然而，MM 的发病机制仅部分被理解。详细的基因组分析显示出结构和数量染色体异常的异质性和复杂性模式。在这篇综述中，我们将讨论 IGF-1R 的一些最新研究结果，IGF-1R 是 MM 生长和存活的主要介质之一。我们还将描述我们在 MM 中关于表观遗传基因沉默的一些结果，因为它确实可能构成理解 MM 中肿瘤起始和维持的新基础，从而可能改变 MM 治疗策略的当前观点。
