多梳抑制复合物 PRC2 及其在生命中的标记。
The Polycomb complex PRC2 and its mark in life.
机构信息
Institut Curie, 26 Rue d'Ulm, 75005 Paris, France.
出版信息
Nature. 2011 Jan 20;469(7330):343-9. doi: 10.1038/nature09784.
Abstract
Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin structure. In mammals, two main Polycomb group complexes exist - Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC1 compacts chromatin and catalyses the monoubiquitylation of histone H2A. PRC2 also contributes to chromatin compaction, and catalyses the methylation of histone H3 at lysine 27. PRC2 is involved in various biological processes, including differentiation, maintaining cell identity and proliferation, and stem-cell plasticity. Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes.
摘要
多梳抑制复合物蛋白通过调节染色质结构来维持不同细胞在早期发育过程中形成的基因表达模式。在哺乳动物中，存在两种主要的多梳抑制复合物——多梳抑制复合物 1（PRC1）和 2（PRC2）。PRC1 使染色质浓缩，并催化组蛋白 H2A 的单泛素化。PRC2 也有助于染色质的浓缩，并催化组蛋白 H3 赖氨酸 27 的甲基化。PRC2 参与多种生物学过程，包括分化、维持细胞特性和增殖以及干细胞可塑性。最近对 PRC2 的研究扩展了我们对其功能和调节的认识，并揭示了非编码 RNA 在募集 PRC2 到靶基因中的作用。
相似文献
1
The Polycomb complex PRC2 and its mark in life.多梳抑制复合物 PRC2 及其在生命中的标记。
Nature. 2011 Jan 20;469(7330):343-9. doi: 10.1038/nature09784.
2
Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements.PRC1与PRC2在招募至多梳反应元件过程中的相互依赖性。
Nucleic Acids Res. 2016 Dec 1;44(21):10132-10149. doi: 10.1093/nar/gkw701. Epub 2016 Aug 23.
3
Histone methylation by PRC2 is inhibited by active chromatin marks.PRC2 介导的组蛋白甲基化受活性染色质标记抑制。
Mol Cell. 2011 May 6;42(3):330-41. doi: 10.1016/j.molcel.2011.03.025.
4
Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation.致密染色质激活 Polycomb 抑制复合物 2 以调节 H3 赖氨酸 27 甲基化。
Science. 2012 Aug 24;337(6097):971-5. doi: 10.1126/science.1225237.
5
Role of the polycomb protein EED in the propagation of repressive histone marks.多梳蛋白EED在抑制性组蛋白标记传播中的作用。
Nature. 2009 Oct 8;461(7265):762-7. doi: 10.1038/nature08398. Epub 2009 Sep 20.
6
Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes.聚梳蛋白抑制复合物2（Pcl-PRC2）是在聚梳靶基因处产生高水平组蛋白H3赖氨酸27三甲基化（H3-K27三甲基化）所必需的。
EMBO J. 2007 Sep 19;26(18):4078-88. doi: 10.1038/sj.emboj.7601837. Epub 2007 Aug 30.
7
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains.对多梳抑制复合体1（PRC1）和多梳抑制复合体2（PRC2）占据情况的全基因组分析确定了两类双价结构域。
PLoS Genet. 2008 Oct;4(10):e1000242. doi: 10.1371/journal.pgen.1000242. Epub 2008 Oct 31.
8
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing.在X染色体失活起始阶段募集PRC1功能，该过程独立于PRC2且与基因沉默相关。
EMBO J. 2006 Jul 12;25(13):3110-22. doi: 10.1038/sj.emboj.7601187. Epub 2006 Jun 8.
9
Polycomb-mediated histone modifications and gene regulation.多梳介导的组蛋白修饰和基因调控。
Biochem Soc Trans. 2024 Feb 28;52(1):151-161. doi: 10.1042/BST20230336.
10
The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.多梳抑制复合物基因产物 Ezh2 调控小鼠肝干细胞/祖细胞的增殖和分化。
J Hepatol. 2010 Jun;52(6):854-63. doi: 10.1016/j.jhep.2010.01.027. Epub 2010 Mar 24.
引用本文的文献
1
Identification and validation of a histone modification-related gene signature to predict the prognosis of multiple myeloma.用于预测多发性骨髓瘤预后的组蛋白修饰相关基因特征的鉴定与验证
Front Genet. 2025 Aug 28;16:1613631. doi: 10.3389/fgene.2025.1613631. eCollection 2025.
2
EZH2 variants derived from cryptic splice sites govern distinct epigenetic patterns during embryonic development.源自隐秘剪接位点的EZH2变体在胚胎发育过程中调控不同的表观遗传模式。
Nucleic Acids Res. 2025 Sep 5;53(17). doi: 10.1093/nar/gkaf869.
3
Interrogating the regulatory epigenome of cellular senescence.探究细胞衰老的调控表观基因组。
Cell Mol Life Sci. 2025 Aug 31;82(1):328. doi: 10.1007/s00018-025-05848-w.
4
Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID.使用ProtacID对PROTAC特异性和内源性蛋白质相互作用组进行表征。
Nat Commun. 2025 Aug 29;16(1):8089. doi: 10.1038/s41467-025-63357-7.
5
Bladder Cancer: Role of Circular RNAs in Oncogenesis, Tumor Suppression, and Therapeutic Target Identification.膀胱癌：环状RNA在肿瘤发生、肿瘤抑制及治疗靶点识别中的作用
Cancer Genomics Proteomics. 2025 Sep-Oct;22(5):654-682. doi: 10.21873/cgp.20528.
6
Histone Modifications as Individual-Specific Epigenetic Regulators: Opportunities for Forensic Genetics and Postmortem Analysis.组蛋白修饰作为个体特异性表观遗传调节因子：法医遗传学和死后分析的机遇
Genes (Basel). 2025 Aug 7;16(8):940. doi: 10.3390/genes16080940.
7
Missense Variants Disrupt Polycomb Repression and Enable Ectopic Mesenchymal Lineage Conversion During Human Neural Differentiation.错义变体破坏多梳抑制并在人类神经分化过程中促成异位间充质谱系转化。
Res Sq. 2025 Aug 11:rs.3.rs-7143352. doi: 10.21203/rs.3.rs-7143352/v1.
8
The epigenetic circle: feedback loops in the maintenance of cellular memory.表观遗传循环：细胞记忆维持中的反馈回路
Epigenetics Chromatin. 2025 Aug 20;18(1):56. doi: 10.1186/s13072-025-00621-6.
9
Druggability assessments of small peptides as protein-protein interaction inhibitors targeting EED-EZH2 binding within the Polycomb Repressive Complex 2 (PRC2), an epigenetic regulator.小肽作为靶向多梳抑制复合物2（PRC2，一种表观遗传调控因子）中EED-EZH2结合的蛋白质-蛋白质相互作用抑制剂的成药潜力评估。
Mol Divers. 2025 Aug 15. doi: 10.1007/s11030-025-11321-4.
10
Functional Comparison to Ezh2 Reveals PRC2-Independent Functions of Jarid2 in Hematopoietic Stem Cell Lineage Commitment.与Ezh2的功能比较揭示了Jarid2在造血干细胞谱系定向分化中的PRC2非依赖性功能。
bioRxiv. 2025 Jul 19:2025.07.18.665536. doi: 10.1101/2025.07.18.665536.
本文引用的文献
1
Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA.PRC2 组件 Ezh2 的磷酸化受细胞周期调控，并上调其与 ncRNA 的结合。
Genes Dev. 2010 Dec 1;24(23):2615-20. doi: 10.1101/gad.1983810.
2
Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.细胞周期蛋白依赖性激酶通过磷酸化 EZH2 调节表观遗传基因沉默。
Nat Cell Biol. 2010 Nov;12(11):1108-14. doi: 10.1038/ncb2116. Epub 2010 Oct 10.
3
Long noncoding RNA as modular scaffold of histone modification complexes.长非编码 RNA 作为组蛋白修饰复合物的模块化支架。
Science. 2010 Aug 6;329(5992):689-93. doi: 10.1126/science.1192002. Epub 2010 Jul 8.
4
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.骨髓增生异常综合征中组蛋白甲基转移酶基因 EZH2 的体细胞突变。
Nat Genet. 2010 Aug;42(8):665-7. doi: 10.1038/ng.620. Epub 2010 Jul 4.
5
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.在髓系疾病中，组蛋白甲基转移酶基因 EZH2 的失活突变。
Nat Genet. 2010 Aug;42(8):722-6. doi: 10.1038/ng.621. Epub 2010 Jul 4.
6
ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.胚胎干细胞需要 PRC2 来指导分化细胞成功重编程为多能性。
Cell Stem Cell. 2010 Jun 4;6(6):547-56. doi: 10.1016/j.stem.2010.04.013.
7
Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2.短 RNA 由受抑制的多梳靶基因转录而来，并与多梳抑制复合物-2 相互作用。
Mol Cell. 2010 Jun 11;38(5):675-88. doi: 10.1016/j.molcel.2010.03.019.
8
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.非编码 RNA ANRIL 与组蛋白 H3 赖氨酸 27 甲基化通过多梳体 CBX7 的相互作用在 INK4a 的转录沉默中。
Mol Cell. 2010 Jun 11;38(5):662-74. doi: 10.1016/j.molcel.2010.03.021.
9
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.Jarid2 是胚胎干细胞中 PRC2 的一个组成部分，对于多谱系分化和 PRC1 和 RNA 聚合酶 II 募集到发育调节剂是必需的。
Nat Cell Biol. 2010 Jun;12(6):618-24. doi: 10.1038/ncb2065. Epub 2010 May 16.
10
Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.Ring1B 紧致染色质结构并抑制基因表达，而不依赖于组蛋白泛素化。
Mol Cell. 2010 May 14;38(3):452-64. doi: 10.1016/j.molcel.2010.02.032.
Zotero 插件