Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Nutr Res. 2012 Feb;32(2):93-9. doi: 10.1016/j.nutres.2011.12.017.
Infants between 6 and 24 months of age are at the highest risk of development of iron deficiency anemia (IDA) in developing countries. Consuming unmodified cow's milk, delayed introduction of solid foods after 6 months, and high birth order could be predictors of the presence of IDA. Three hundred infants between the ages of 6 and 24 months (mean, 13.94 ± 6.17 months) from Ain Shams University Children's Hospital were enrolled in the study. Data collected included demographic information and dietary assessment including the type of milk feeding, introduction of solid foods, and daily iron intake. The infants were examined, and anthropometric measurements were recorded. Anemic infants (hemoglobin level <11 g/dL) were further evaluated by complete blood count, hemoglobin electrophoresis, and iron profile. Anemia was diagnosed among 198 infants (66%), of whom 129 (43%) had IDA. Red cell distribution width at a cutoff value of 15.8% was 86% sensitive and 74% specific in predicting IDA. The main risk factors for IDA included being between 6 and 18 months of age, of the male sex, birth order above the second order, consuming cow's milk, predominant breast-feeding beyond 6 months of age, and low daily iron intake. We conclude that IDA is the most common cause of anemia among Egyptian infants 6 to 24 months old of low socioeconomic standard. Independent clinical predictors were consuming cow's milk during the first 6 months, delayed introduction of solid foods after 6 months, and birth order beyond the second order.
6 至 24 个月龄的婴儿在发展中国家缺铁性贫血(IDA)的发病风险最高。食用未经改良的牛奶、6 个月后固体食物引入延迟以及较高的出生顺序可能是 IDA 存在的预测因素。本研究纳入了 300 名来自 Ain Shams 大学儿童医院的 6 至 24 个月龄(平均 13.94±6.17 个月)的婴儿。收集的数据包括人口统计学信息和饮食评估,包括牛奶喂养类型、固体食物引入和每日铁摄入量。对婴儿进行了检查,并记录了人体测量学测量值。对贫血婴儿(血红蛋白水平<11g/dL)进行了进一步评估,包括全血细胞计数、血红蛋白电泳和铁谱。198 名婴儿(66%)被诊断为贫血,其中 129 名(43%)患有 IDA。红细胞分布宽度截断值为 15.8%时,对 IDA 的敏感性为 86%,特异性为 74%。IDA 的主要危险因素包括年龄在 6 至 18 个月、男性、出生顺序高于第二顺序、食用牛奶、6 个月后母乳喂养为主以及每日铁摄入量低。我们得出结论,IDA 是埃及低社会经济标准 6 至 24 个月龄婴儿贫血的最常见原因。独立的临床预测因素包括在出生后 6 个月内食用牛奶、6 个月后固体食物引入延迟以及出生顺序超过第二顺序。