The Hospital for Sick Children - Arthur and Sonia Labatt Brain Tumour Research Centre, Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Canada.
Nanomedicine. 2012 Oct;8(7):1133-42. doi: 10.1016/j.nano.2012.02.003. Epub 2012 Feb 17.
The blood brain barrier (BBB) is a major impediment to the delivery of therapeutics into the central nervous system (CNS). Gold nanoparticles (AuNPs) have been successfully employed in multiple potential therapeutic and diagnostic applications outside the CNS. However, AuNPs have very limited biodistribution within the CNS following intravenous administration. Magnetic resonance imaging guided focused ultrasound (MRgFUS) is a novel technique that can transiently increase BBB permeability allowing delivery of therapeutics into the CNS. MRgFUS has not been previously employed for delivery of AuNPs into the CNS. This work represents the first demonstration of focal enhanced delivery of AuNPs into the CNS using MRgFUS in a rat model both safely and effectively. Histologic visualization and analytical quantification of AuNPs within the brain parenchyma suggest BBB transgression. These results suggest a role for MRgFUS in the delivery of AuNPs with therapeutic potential into the CNS for targeting neurological diseases.
Gold nanoparticles have been successfully utilized in experimental diagnostic and therapeutic applications; however, the blood-brain barrier (BBB) is not permeable to these particles. In this paper, the authors demonstrated that MRI guided focused ultrasound is capable to transiently open the BBB thereby enabling CNS access.
血脑屏障（BBB）是治疗药物进入中枢神经系统（CNS）的主要障碍。金纳米颗粒（AuNPs）已成功应用于 CNS 以外的多种潜在治疗和诊断应用中。然而，静脉给药后，AuNPs 在 CNS 内的生物分布非常有限。磁共振成像引导聚焦超声（MRgFUS）是一种新的技术，可以短暂增加 BBB 的通透性，使治疗药物进入 CNS。MRgFUS 以前从未用于将 AuNPs 递送到 CNS。这项工作首次证明了在大鼠模型中，MRgFUS 可安全有效地将 AuNPs 递送至 CNS 进行靶向治疗。脑实质内 AuNPs 的组织学可视化和分析定量表明 BBB 通透性增加。这些结果表明，MRgFUS 在将具有治疗潜力的 AuNPs 递送至 CNS 以靶向神经疾病方面具有重要作用。
金纳米颗粒已成功用于实验诊断和治疗应用；然而，血脑屏障（BBB）对这些颗粒是不可渗透的。在本文中，作者证明了 MRI 引导的聚焦超声能够短暂地打开 BBB，从而使 CNS 能够进入。
