Centre de Génétique Moléculaire du CNRS, UPR 3404, FRC3115, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
Mitochondrion. 2012 May;12(3):381-90. doi: 10.1016/j.mito.2012.02.002. Epub 2012 Feb 10.
Complexes III and IV of the mitochondrial respiratory chain contain a few key subunits encoded by the mitochondrial genome. In Saccharomyces cerevisiae, fifteen mRNA-specific translational activators control mitochondrial translation, of which five are conserved in Schizosaccharomyces pombe. These include homologs of Cbp3, Cbp6 and Mss51 that participate in translation and the post-translational steps leading to the assembly of respiratory complexes III and IV. In this study we show that in contrast to budding yeast, Cbp3, Cbp6 and Mss51 from S. pombe are not required for the translation of mitochondrial mRNAs, but fulfill post-translational functions, thus probably accounting for their conservation.
线粒体呼吸链复合物 III 和 IV 包含少数几个由线粒体基因组编码的关键亚基。在酿酒酵母中，十五种 mRNA 特异性翻译激活因子控制线粒体翻译，其中五种在粗糙脉孢菌中保守。这些包括参与翻译和导致呼吸复合物 III 和 IV 组装的翻译后步骤的 Cbp3、Cbp6 和 Mss51 的同源物。在这项研究中，我们表明与出芽酵母相反，来自 S. pombe 的 Cbp3、Cbp6 和 Mss51 不参与线粒体 mRNA 的翻译，但具有翻译后功能，因此可能解释了它们的保守性。
