Abteilung für Biochemie II, Universität Göttingen, D-37073 Göttingen, Germany.
Nat Rev Mol Cell Biol. 2011 Jan;12(1):14-20. doi: 10.1038/nrm3029.
Mitochondria maintain genome and translation machinery to synthesize a small subset of subunits of the oxidative phosphorylation system. To build up functional enzymes, these organellar gene products must assemble with imported subunits that are encoded in the nucleus. New findings on the early steps of cytochrome c oxidase assembly reveal how the mitochondrial translation of its core component, cytochrome c oxidase subunit 1 (Cox1), is directly coupled to the assembly of this respiratory complex.
线粒体维持基因组和翻译机制，以合成氧化磷酸化系统的一小部分亚基。为了构建功能性酶，这些细胞器基因产物必须与核编码的导入亚基组装。细胞色素 c 氧化酶组装早期步骤的新发现揭示了线粒体如何将其核心组件细胞色素 c 氧化酶亚基 1（Cox1）的翻译直接与该呼吸复合物的组装偶联。
