Department of Health Behavior and Health Education, UNC Gillings School of Global Public Health, CB#7440, Chapel Hill, NC 27599, USA.
J Behav Med. 2012 Apr;35(2):115-23. doi: 10.1007/s10865-012-9405-5. Epub 2012 Feb 16.
Few studies have explored mediators between medication-related support and medication adherence for individuals with rare, systemic autoimmune conditions. Using the Information-Motivation-Behavioral Skills model, we tested whether depressive symptomatology and medication adherence self-efficacy mediated the relationship between adherence support and changes in medication adherence among vasculitis patients, and whether support from physicians and partners differentially affected medication adherence. Vasculitis patients (n = 172) completed baseline and follow-up questionnaires about their medication adherence and perceived adherence support. Bootstrapped mediation analyses tested the effects of physician and partner support on changes in medication adherence. Adherence self-efficacy mediated the relationship between physician support and changes in medication adherence (B = 0.05, SE = 0.03, 95% CI 0.01, 0.13). Neither self-efficacy nor depressive symptomatology mediated the effects of partner support. Although physicians spend little time with patients, they can increase patients' confidence about taking medications correctly and potentially improve health outcomes by bolstering medication adherence.
很少有研究探讨过与个体罕见的系统性自身免疫性疾病相关的药物治疗支持与药物依从性之间的中介因素。本研究利用信息-动机-行为技能模型，测试了血管炎患者的抑郁症状和药物依从性自我效能是否在药物依从性支持与药物依从性变化之间起中介作用，以及医生和伴侣的支持是否对药物依从性有不同的影响。血管炎患者（n=172）完成了关于他们的药物依从性和感知到的药物依从性支持的基线和随访问卷。Bootstrapped 中介分析测试了医生和伴侣支持对药物依从性变化的影响。依从性自我效能在医生支持与药物依从性变化之间起中介作用（B=0.05，SE=0.03，95%置信区间 0.01，0.13）。自我效能和抑郁症状都没有中介伴侣支持的影响。尽管医生与患者在一起的时间很少，但他们可以通过增强药物依从性来增加患者正确服药的信心，并有可能改善健康结果。
