Altan Tugrul, Acar Nur, Kapran Ziya, Unver Yaprak B, Ozdogan Sezin
Beyoglu Eye Training And Research Hospital, Konaklar Mah., Hukukcular sitesi C/4 No. 18, 4 Levent, 34330, Istanbul, Turkey.
Int Ophthalmol. 2012 Apr;32(2):119-25. doi: 10.1007/s10792-012-9532-6. Epub 2012 Feb 19.
To evaluate the outcome of photodynamic therapy (PDT) and the factors influencing its outcome in patients with subfoveal choroidal neovascularization (CNV) due to pathologic myopia. Twenty-three eyes of 21 consecutive patients who received PDT for subfoveal CNV due to pathologic myopia and who were followed for >12 months were included in the study. The relationship between the factors that might affect the treatment outcome were evaluated. Mean age was 48.7 ± 16.0 years (23-74 years). Mean follow-up was 23.2 ± 7.7 months (15-41 months). Mean logMAR visual acuity was 0.85 ± 0.24 before treatment, 0.89 ± 0.37 at 12 months, and 0.92 ± 0.46 at the final visit. Mean logMAR visual acuity did not change significantly at 12 months or at the final visit (P = 0.47 and 0.36, respectively). The baseline visual acuity strongly correlated with the final visual acuity (P = 0.001). Age showed an inverse correlation with change in logMAR visual acuity at 12 months (P = 0.01). PDT prevented significant visual loss in eyes with subfoveal CNV due to pathologic myopia. Better initial visual acuity resulted in better final visual acuity. Younger age was correlated with better treatment outcome at 12 months.
评估病理性近视所致黄斑下脉络膜新生血管（CNV）患者光动力疗法（PDT）的疗效及其影响因素。本研究纳入了21例连续患者的23只眼，这些患者因病理性近视接受了黄斑下CNV的PDT治疗且随访时间超过12个月。评估了可能影响治疗效果的因素之间的关系。平均年龄为48.7±16.0岁（23 - 74岁）。平均随访时间为23.2±7.7个月（15 - 41个月）。治疗前平均logMAR视力为0.85±0.24，12个月时为0.89±0.37，末次随访时为0.92±0.46。12个月时和末次随访时平均logMAR视力均无显著变化（分别为P = 0.47和0.36）。基线视力与最终视力密切相关（P = 0.001）。年龄与12个月时logMAR视力变化呈负相关（P = 0.01）。PDT可预防病理性近视所致黄斑下CNV患者的严重视力丧失。初始视力越好，最终视力越好。年龄越小，12个月时的治疗效果越好。
