Department of Dermatology, Medical University Innsbruck, Innsbruck, Austria.
Arch Dermatol Res. 2012 Apr;304(3):185-93. doi: 10.1007/s00403-012-1222-8. Epub 2012 Feb 17.
Multiple functional implications have been suggested for a limited number of chemokines and their cognate receptors in melanoma pathogenesis. The purpose of this study was to investigate the potential role of the chemokine receptors CXCR4, CCR7, CCR9, and CCR10 as prognostic markers in human primary cutaneous melanoma. Chemokine receptor expression was analyzed by immunohistochemistry in a total of 38 patients with cutaneous melanoma. Results were statistically correlated with melanoma features and clinical disease progression. No significant correlation between overexpression of CXCR4 or CCR9 and survival or prognosis was found. CCR7 overexpression was associated with significantly lower survival (0.005 log rank) and shorter time to progression (0.009 log rank)-similar to CCR10 overexpression (lower survival: 0.001 log rank, shorter time to progression: 0.002 log rank). In addition, CCR7 overexpression correlated with expression of metallothionein, while CCR10 seems to be associated with cerebral metastases. Two chemokine receptors permitting the identification of high-risk patients were identified: CCR7 and CCR10 overexpressions were found to be associated with a worse outcome of disease course independent of Breslow's tumor thickness and Clark level, thus representing possible additional prognostic markers.
在黑色素瘤发病机制中，少数趋化因子及其同源受体具有多种功能意义。本研究旨在探讨趋化因子受体 CXCR4、CCR7、CCR9 和 CCR10 作为人类原发性皮肤黑色素瘤预后标志物的潜在作用。通过免疫组织化学分析了总共 38 例皮肤黑色素瘤患者的趋化因子受体表达。结果与黑色素瘤特征和临床疾病进展进行了统计学相关性分析。未发现 CXCR4 或 CCR9 的过表达与生存或预后相关。CCR7 的过表达与生存率显著降低（0.005 对数秩）和进展时间缩短（0.009 对数秩）相关，与 CCR10 的过表达相似（生存率降低：0.001 对数秩，进展时间缩短：0.002 对数秩）。此外，CCR7 的过表达与金属硫蛋白的表达相关，而 CCR10 似乎与脑转移有关。确定了两种允许识别高危患者的趋化因子受体：CCR7 和 CCR10 的过表达与疾病进程的不良预后相关，独立于 Breslow 肿瘤厚度和 Clark 分级，因此代表了可能的额外预后标志物。
