基质金属蛋白酶、炎症和癌症的三位一体：最新文献综述。
The Trinity of Matrix Metalloproteinases, Inflammation, and Cancer: A Literature Review of Recent Updates.
机构信息
Department of Biochemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
出版信息
Antiinflamm Antiallergy Agents Med Chem. 2020;19(3):206-221. doi: 10.2174/1871523018666191023141807.
Abstract
The critical link between cancer and inflammation has been known for many years. This complex network was further complexed by revealing the association of the matrix metalloproteinase family members with inflammatory cytokines, which were previously known to be responsible for the development of metastasis. This article summarizes the current studies which evaluate the relationship between cancer and inflammatory microenvironment as well as the roles of MMPs on invasion and metastasis together.
摘要
多年来，人们已经认识到癌症和炎症之间的关键联系。通过揭示基质金属蛋白酶家族成员与先前已知负责转移发展的炎症细胞因子之间的关联，这一复杂网络变得更加复杂。本文总结了目前评估癌症与炎症微环境之间关系的研究，以及 MMPs 在侵袭和转移中的作用。
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