Westlund Karin N, Vera-Portocarrero Louis
Department of Physiology, Chandler Medical Center, University of Kentucky, Lexington, KY, USA.
Methods Mol Biol. 2012;851:223-38. doi: 10.1007/978-1-61779-561-9_17.
Pancreatic pain is often severe and difficult to treat clinically. Many animal models that mimic pancreatic pain are typically short term and invasive in nature. The present chapter describes the development and characterization of two non-invasive rat models of pancreatitis, one acute and one chronic. The two models described here are simple to replicate, giving them advantage over other animal models of pancreatic inflammation. A goal of this chapter is also to detail their usefulness as visceral pain models.
胰腺疼痛通常很严重，临床上难以治疗。许多模拟胰腺疼痛的动物模型通常是短期的且具有侵入性。本章描述了两种非侵入性大鼠胰腺炎模型的建立和特征，一种是急性模型，一种是慢性模型。这里描述的这两种模型易于复制，这使其比其他胰腺炎症动物模型更具优势。本章的一个目标还在于详细阐述它们作为内脏疼痛模型的实用性。
