Department of Gastroenterology and Hepatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita15 Nishi7, Kita-ku, Sapporo, 060-8638, Japan.
Division of Endoscopy, Hokkaido University Hospital, Kita14 Nishi5, Kita-ku, Sapporo, 060-8648, Japan.
J Gastroenterol. 2018 Jan;53(1):1-5. doi: 10.1007/s00535-017-1363-9. Epub 2017 Jun 23.
Mesenchymal stem cells (MSCs) have attracted attention as a cell source for regenerative medicine. In particular, MSCs have an anti-inflammatory effect by secreting several kinds of bioactive molecules. MSC therapy is now being applied to various gastrointestinal diseases, such as graft-versus-host disease, inflammatory bowel disease, and liver cirrhosis. Therefore, MSC therapy has the potential to be a novel treatment for acute and chronic pancreatitis by suppressing inflammation. Several studies have investigated the effect of MSC therapy on acute and chronic pancreatitis, but the underlying mechanisms remain unknown. In this review, we summarize the present status of MSC therapy for acute and chronic pancreatitis.
间充质干细胞（MSCs）作为再生医学的细胞来源受到关注。特别是，MSCs 通过分泌几种生物活性分子发挥抗炎作用。MSC 疗法现正应用于各种胃肠道疾病，如移植物抗宿主病、炎症性肠病和肝硬化。因此，MSC 疗法通过抑制炎症，有可能成为急性和慢性胰腺炎的一种新的治疗方法。有几项研究探讨了 MSC 疗法对急性和慢性胰腺炎的影响，但潜在机制尚不清楚。在这篇综述中，我们总结了 MSC 疗法治疗急性和慢性胰腺炎的现状。
