Grummer M A, Zachman R D
University of Wisconsin Perinatal Center, Department of Pediatrics and Nutritional Sciences, Meriter Hospital, Madison 53715.
Pediatr Res. 1990 Sep;28(3):186-9. doi: 10.1203/00006450-199009000-00002.
The effect of maternal ethanol ingestion on fetal tissue vitamin A was investigated. Pregnant rats were pair-fed control diets or diets containing 36% of energy as ethanol. After 17 or 21 d gestation, fetuses were removed and fetal and maternal tissues were analyzed by HPLC for retinol and retinyl palmitate. Ethanol consumption resulted in fewer fetuses per pregnancy, increased number of resorptions, and increased numbers of gross fetal abnormalities. In maternal tissues, ethanol consumption resulted in greater lung and kidney vitamin A concentrations. In the fetuses of ethanol-consuming pregnancies, free retinol in liver was higher at d 17. However, fetal liver palmitate levels and total retinyl palmitate in liver, lung, and kidney were lower in ethanol-fed rats at d 21 of gestation. Fetal lung retinyl palmitate concentrations were greater at both d 17 and d 21, and kidney levels were also greater at d 21. In conclusion, the ingestion of ethanol by pregnant rats is associated with a reduction in fetal liver vitamin A levels and an elevation in the levels of lung and kidney vitamin A, indicating possible altered vitamin A metabolism as a result of ethanol consumption.
研究了母体摄入乙醇对胎儿组织维生素A的影响。将怀孕大鼠成对喂养对照饮食或含36%能量为乙醇的饮食。妊娠17天或21天后，取出胎儿，用高效液相色谱法分析胎儿和母体组织中的视黄醇和棕榈酸视黄酯。摄入乙醇导致每次妊娠的胎儿数量减少、吸收数量增加以及严重胎儿异常数量增加。在母体组织中，摄入乙醇导致肺和肾中的维生素A浓度升高。在摄入乙醇的妊娠胎儿中，肝脏中的游离视黄醇在第17天时较高。然而，在妊娠第21天时，乙醇喂养大鼠的胎儿肝脏棕榈酸酯水平以及肝脏、肺和肾中的总棕榈酸视黄酯水平较低。胎儿肺中棕榈酸视黄酯浓度在第17天和第21天时均较高，肾脏水平在第21天时也较高。总之，怀孕大鼠摄入乙醇与胎儿肝脏维生素A水平降低以及肺和肾中维生素A水平升高有关，表明摄入乙醇可能改变了维生素A的代谢。
