Lin G W
Curr Alcohol. 1981;8:479-83.
The distribution of 14C-alpha-aminoisobutyric acid (AIB), administered intravenously, in maternal, fetal and placental tissues was examined in the rat on gestation-day 21. Ethanol consumption during gestation (day 6 through 21) significantly reduced the uptake of AIB by the placenta and fetus while exerting no influence on maternal tissue AIB uptake. The concentration of fetal plasma free histidine was decreased 50% as a result of maternal ethanol ingestion, but the free histidine level of maternal plasma was not altered. Since no effect on protein content of fetal tissue could be detected, it is speculated that reduced histidine to the fetus might significantly alter the amounts of histamine and carnosine formed via their precursor. The significance of these findings in relation to the Fetal Alcohol Syndrome is discussed.
在妊娠第21天的大鼠中，研究了静脉注射14C-α-氨基异丁酸（AIB）在母体、胎儿和胎盘组织中的分布情况。孕期（第6天至第21天）摄入乙醇显著降低了胎盘和胎儿对AIB的摄取，而对母体组织摄取AIB没有影响。母体摄入乙醇导致胎儿血浆游离组氨酸浓度降低50%，但母体血浆游离组氨酸水平未改变。由于未检测到对胎儿组织蛋白质含量的影响，推测胎儿组氨酸减少可能会显著改变经由其前体形成的组胺和肌肽的量。讨论了这些发现与胎儿酒精综合征的相关性。
