线粒体损伤的原因及后果：形态学方面

Causes and consequences of damage to mitochondria : morphological aspects.

作者信息

Miquel J, Bertoni-Freddari C

机构信息

Institute of Neurosciences, Faculty of Medicine, Miguel Hernandez University, San Juan, Alicante, Spain.

出版信息

Methods Mol Med. 2000;38:221-35. doi: 10.1385/1-59259-070-5:221.

DOI:10.1385/1-59259-070-5:221

PMID:22351278

Abstract

In recent years the role played by mitochondria in cellular aging has become the focus of intensive research. The concept that these energy-producing organelles are involved in aging derives from the views of Harman (1) and Gerschman (2) linking senescence to the damaging effects of free radicals, especially those released in the mitochondrial respiratory chain.

摘要

近年来，线粒体在细胞衰老过程中所起的作用已成为深入研究的焦点。这些产生能量的细胞器与衰老相关的概念源于哈曼（1）和格施曼（2）的观点，他们将衰老与自由基的破坏作用联系起来，尤其是线粒体呼吸链中释放的自由基。