Global R&D, ISP Corporation, Wayne, NJ, USA.
J Cosmet Dermatol. 2010 Jun;9(2):122-31. doi: 10.1111/j.1473-2165.2010.00496.x.
Mitochondria, long considered to have the primary role in cellular energetic, have been the center of much research interest in the recent past. Technological advances in microscopy and development of new and specific fluorescent dyes for visualization of mitochondrial dynamics in living cells have facilitated the newfound interest in these fascinating organelles, which are now implicated in diverse cellular functions crucial in health and disease. Mitochondria play crucial roles in several age-related diseases, and in the physiology of normal aging. In this review, we discuss the structural and functional aspects of mitochondria and their implications to the aging process, as well as its significance to skin aging. Available information on active molecules that can impact the mitochondrial functions, and their potential use in skin care products is also discussed, highlighting these organelles as a new focus for anti-aging strategies in personal care.
线粒体，长期以来被认为在细胞能量中起主要作用，在最近的过去一直是许多研究的焦点。显微镜技术的进步和新的、特异性荧光染料的开发，使得人们能够在活细胞中可视化线粒体动力学，这激发了人们对这些迷人细胞器的新兴趣，这些细胞器现在与健康和疾病中至关重要的多种细胞功能有关。线粒体在几种与年龄相关的疾病以及正常衰老的生理学中起着关键作用。在这篇综述中，我们讨论了线粒体的结构和功能及其对衰老过程的影响，以及它对皮肤衰老的意义。还讨论了可影响线粒体功能的活性分子的现有信息及其在护肤品中的潜在用途，强调这些细胞器是个人护理抗衰老策略的新焦点。
