Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Fuku-ura 3-9, Kanazawa Ward, Yokohama 236-0004, Japan.
Mol Neurobiol. 2012 Apr;45(2):234-46. doi: 10.1007/s12035-012-8242-4. Epub 2012 Feb 18.
Collapsin response mediator protein (CRMP) was originally identified as a molecule involved in semaphorin3A signaling. CRMPs are now known to consist of five homologous cytosolic proteins, CRMP1-5. All of them are phosphorylated and highly expressed in the developing and adult nervous system. In vitro experiments have clearly demonstrated that CRMPs play important roles in neuronal development and maturation through the regulation of their phosphorylation. Several recent knockout mice studies have revealed in vivo roles of CRMPs in neuronal migration, neuronal network formation, synapse formation, synaptic plasticity, and neuronal diseases. Dynamic spatiotemporal regulation of phosphorylation status of CRMPs is involved in many aspects of neuronal development.
collapsin 反应介质蛋白 (CRMP) 最初被鉴定为参与信号 semaphorin3A 的分子。现在已知 CRMP 由五个同源胞质蛋白 CRMP1-5 组成。它们在发育和成年神经系统中均高度表达并发生磷酸化。体外实验清楚地表明，CRMP 通过调节其磷酸化在神经元发育和成熟中发挥重要作用。最近的一些敲除小鼠研究揭示了 CRMP 在神经元迁移、神经元网络形成、突触形成、突触可塑性和神经元疾病中的体内作用。CRMP 磷酸化状态的动态时空调节参与了神经元发育的许多方面。
