Charrier Emmanuelle, Reibel Sophie, Rogemond Véronique, Aguera Michèle, Thomasset Nicole, Honnorat Jérôme
Institut National de la Santé et de la Recherche Médicale U 433, Hôpital Neurologique, 59 Bd Pinel, 69003 Lyon, France.
Mol Neurobiol. 2003 Aug;28(1):51-64. doi: 10.1385/MN:28:1:51.
The members of the collapsin response mediator protein (CRMP) family-five cytosolic phosphoproteins -are highly expressed throughout brain development. The first member to be cloned, CRMP2, was identified as an intracellular messenger required for the growth cone-collapse induced by semaphorin 3A (Sema3A). A rapidly expanding body of study indicates that the functions of CRMPs are not solely limited to the signaling transduction of the Sema3A guidance cue. They are probably involved in multiple cellular and molecular events involved in apoptosis/proliferation, cell migration, and differentiation. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity and also in a subpopulation of oligodendrocytes (CRMP2 and CRMP5). Moreover, the expression of CRMPs is altered in neurodegenerative diseases, and these proteins may be of key importance in the physiopathology of the adult nervous system.
塌陷反应中介蛋白（CRMP）家族的成员——五种胞质磷蛋白——在整个大脑发育过程中高度表达。第一个被克隆的成员CRMP2，被鉴定为是由信号素3A（Sema3A）诱导的生长锥塌陷所必需的细胞内信使。一项迅速扩展的研究表明，CRMP的功能不仅限于Sema3A引导信号的信号转导。它们可能参与了凋亡/增殖、细胞迁移和分化等多个细胞和分子事件。在成人大脑中，CRMP的表达显著下调。然而，它们仍在保留分化和可塑性能力的结构中表达，也在少突胶质细胞亚群（CRMP2和CRMP5）中表达。此外，CRMP的表达在神经退行性疾病中发生改变，这些蛋白质可能在成体神经系统的生理病理学中具有关键重要性。
