Second Department of Obstetrics and Gynecology, University of Athens Medical School, Athens, Greece.
In Vivo. 2012 Mar-Apr;26(2):327-33.
We investigated the associations between second trimester amniotic fluid (AF) levels of human adiponectin and placental growth factor (PLGF) in small for gestational age (SGA), large for gestational age (LGA) and appropriate for gestational age (AGA) fetuses.
Adiponectin and PLGF levels were determined by enzyme immunoassay in AF of 21 SGA, 13 LGA and 44 AGA fetuses between 15-22 weeks of gestation, derived from pregnant women who underwent amniocentesis.
Adiponectin and PLGF levels were detectable in AF. Median (25th-75th percentile) adiponectin levels were 16.1 (10.9-32.3) ng/ml in SGA, 19.5 (15.1-30.9) ng/ml in AGA, and 18.2 (14.7-30.8) ng/ml in LGA fetuses. Median (25th-75th percentile) PLGF levels were 24.2 (19.9-34.9) pg/nl in SGA, 26.4 (20.9-33.8) pg/ml in AGA and 33.5 (21.8-40.4) pg/ml in LGA fetuses. The differences were not statistically significant. Nevertheless, indication of differentiation of levels existed when SGA and LGA fetuses in the extremes of distribution were considered. Specifically, very severely SGA fetuses (≤2.5th percentile) tended to have high levels of adiponectin and reduced levels of PLGF in AF.
This is the first study presenting adiponectin and PLGF concentrations in early second trimester amniotic fluid in AGA, SGA and LGA fetuses. The altered concentrations of adiponectin and PLGF in very severely SGA fetuses possibly result from the growth-promoting effect of these factors through the metabolic route and the vascular integrity of the placenta, respectively.
我们研究了在小于胎龄儿（SGA）、大于胎龄儿（LGA）和适于胎龄儿（AGA）胎儿的羊水中，妊娠中期的人脂联素和胎盘生长因子（PLGF）水平与羊水之间的关系。
我们采用酶联免疫吸附法检测了 21 例 15-22 周妊娠时因羊膜穿刺术而抽取羊水的 SGA、13 例 LGA 和 44 例 AGA 胎儿羊水中的脂联素和 PLGF 水平。
我们在羊水中检测到了脂联素和 PLGF。SGA 胎儿的脂联素中位数（25-75 百分位数）为 16.1（10.9-32.3）ng/ml，AGA 胎儿为 19.5（15.1-30.9）ng/ml，LGA 胎儿为 18.2（14.7-30.8）ng/ml。SGA 胎儿的 PLGF 中位数（25-75 百分位数）为 24.2（19.9-34.9）pg/nl，AGA 胎儿为 26.4（20.9-33.8）pg/ml，LGA 胎儿为 33.5（21.8-40.4）pg/ml。这些差异没有统计学意义。然而，当考虑分布范围 extremes 的 SGA 和 LGA 胎儿时，存在水平分化的迹象。具体来说，非常严重的 SGA 胎儿（≤第 2.5 百分位数）的羊水脂联素水平较高，PLGF 水平较低。
这是首次在 AGA、SGA 和 LGA 胎儿的妊娠中期羊水中检测到脂联素和 PLGF 浓度。非常严重的 SGA 胎儿中脂联素和 PLGF 浓度的改变可能是由于这些因素通过代谢途径和胎盘血管完整性发挥生长促进作用所致。
