Watanabe Yoshihiro, Tsuji Megumi, Sameshima Kiyoko, Wada Takahito, Iai Mizue, Yamashita Sumimasa, Hayashi Takuya, Aida Noriko, Osaka Hitoshi
Division of Neurology, Kanagawa Children's Medical Center, Yokohama, Kanagawa.
No To Hattatsu. 2012 Jan;44(1):35-40.
We report 12 cases of acute encephalopathy associated with influenza H1N1-2009 treated according to Japanese guideline (2009). In all 12 cases, electroencephalogram presented diffuse or localized high-amplitude slow waves. Brain CT and MRI showed abnormalities in 4 and 6 cases, respectively. We used hypothermia therapy for 5 patients. One patient showed impairment in short term memory, while the rest of the patients showed no sequelae. These 12 cases presented here suggest the early recognition and therapy according to the newly proposed guideline may reduce severe sequelae and mortality by acute encephalopathy associated with influenza H1N1-2009.
我们报告了12例按照日本指南（2009年）治疗的与2009年甲型H1N1流感相关的急性脑病病例。在所有12例病例中，脑电图均呈现弥漫性或局限性高幅慢波。脑部CT和MRI检查分别在4例和6例中显示出异常。我们对5例患者采用了低温疗法。1例患者出现短期记忆损害，其余患者均未出现后遗症。此处报告的这12例病例表明，根据新提出的指南进行早期识别和治疗，可能会降低与2009年甲型H1N1流感相关的急性脑病的严重后遗症和死亡率。
