Saha S K, Saha S K, Masud H, Islam N, Raihan A S M A, Roy P K, Hasan M
Department of Gastroenterology, Sir Salimullah Medical College & Mitford Hospital, Dhaka.
Bangladesh Med Res Counc Bull. 2011 Dec;37(3):83-7. doi: 10.3329/bmrcb.v37i3.9118.
Helicobacter pylori eradication is the mainstay in the treatment of Helicobacter pylori associated peptic ulcer disease. Furazolidone was tried in several developing countries and showed good results in some trials. Increasing the duration of treatment has been shown to improve the eradication rate. This study was done to compare the efficacy of triple therapy for two weeks (Group-A) and three weeks (Group-B) consisting of omeprazole 20 mg b.d. amoxicillin 1 gm b.d. and furazolidone 200 mg b.d. in the eradication of Helicobacter pylori in duodenal ulcer patient. A total of 70 duodenal ulcer patients with Helicobacter pylori infection were included in the study. Healing of duodenal ulcer was assessed three months after the end of treatment and at the same time Helicobacter pylori eradication assessed by Campylobacter Like Organism (CLO) test and histology. In group-A, duodenal ulcer was healed in 17 (58.62%) patients and Helicobacter pylori was eradicated in 15 (52%) patients. In group-B, duodenal ulcer was healed in 19 (61.30%) patients and Helicobacter pylori was eradicated in 18 (58%) patients. Healing of duodenal ulcer was not significantly different between two groups. Eradication of Helicobacter pylori was also not significantly different between two groups.
根除幽门螺杆菌是治疗幽门螺杆菌相关性消化性溃疡疾病的主要方法。在一些发展中国家试用了呋喃唑酮，并且在一些试验中显示出良好的效果。已证明延长治疗时间可提高根除率。本研究旨在比较由奥美拉唑20毫克每日两次、阿莫西林1克每日两次和呋喃唑酮200毫克每日两次组成的两周三联疗法（A组）和三周三联疗法（B组）在根除十二指肠溃疡患者幽门螺杆菌方面的疗效。共有70例感染幽门螺杆菌的十二指肠溃疡患者纳入本研究。在治疗结束三个月后评估十二指肠溃疡的愈合情况，同时通过弯曲菌样生物体（CLO）试验和组织学评估幽门螺杆菌的根除情况。在A组中，17例（58.62%）患者的十二指肠溃疡愈合，15例（52%）患者的幽门螺杆菌被根除。在B组中，19例（61.30%）患者的十二指肠溃疡愈合，18例（58%）患者的幽门螺杆菌被根除。两组之间十二指肠溃疡的愈合情况无显著差异。两组之间幽门螺杆菌的根除情况也无显著差异。
