Berkovitz Ronny, Arieli Mickey, Marom Eli
Pharmaceutical Crime Unit, Ministry of Health, Jerusalem, Israel.
Harefuah. 2011 Dec;150(12):884-7, 937.
Recently, a new Law, named the "derivative law" (first addition, schedule drug change--2010), was accepted in the Israeli parliament. It will mean that dangerous substances that are closely related structurally to a drug that is listed in the dangerous drugs ordinance will automatically enter the dangerous drugs ordinance. The dangerous drugs that were sold in kiosks were related to 4 major groups: Amphetamines, methamphetamines, cathinone and methcathinone. Over 90% of the substances known as "legal highs" or "hagigat" belong to these groups. Before the law was accepted, merchandisers and clandestine Laboratories took advantage of a state in which every small molecular change in a controlled substance of amphetamines, methamphetamines, cathinone and methcathinone required a long legal process in order to include the new substance in the controlled substance law. During this process, we believe that public health was endangered. The chemists and merchandisers found a new solution to "legally" bypass the "derivative law", by marketing a new group of substances named "synthetic cannabinoids". The synthetic cannabinoids do not resemble the chemical structure of tetrahydrocannabinol (THC] which appears in marijuana or hashish, but affects the body in the same manner and according to the literature, are five times more potent. The synthetic cannabinoids are sold in Israel under different nicknames such as: "Mabsuton", "Mr. Nice Guy", "Spice", "Sabbaba" and "Lemon Grass". The substance can be used in different ways such as smoking, inhaling or swallowing. The use of synthetic cannabinoids causes side effects that include: euphoria, dizziness, headache, thirst, paranoia, insomnia, fatigue and disturbed vision. Cases of hospital admission in Israel due to the use of these substances have been reported. The symptoms included psychiatric disturbances. In an urgent meeting of the multi-ministry committee on psychotropic substances held in December 2010 in the Israel Anti-Drug Authority, it was decided to recommend to the Minister of Health to insert an inclusive group of "synthetic cannabinoids" into the control drug list in Israel. On April 5, 2011, after receiving the approval of the health and welfare committee in the Israeli parliament, the dangerous drugs ordinance (new version)--5732-1973 was amended with the addition of an inclusive group of "synthetic cannabinoids". These include: JWH-018, JWH-133, JWH-073, CP 47, 497, CP 55, 940, HU-331, HU-210, HU-211, HU-250.
最近，以色列议会通过了一项新法律，即“衍生法”（首次增补，附表药物变更——2010年）。这意味着在结构上与《危险药物条例》中所列药物密切相关的危险物质将自动纳入《危险药物条例》。在报亭出售的危险药物涉及4个主要类别：安非他明、甲基安非他明、卡西酮和甲基卡西酮。超过90%被称为“合法兴奋剂”或“哈吉加特”的物质属于这些类别。在该法律通过之前，经销商和秘密实验室利用了这样一种状况，即安非他明、甲基安非他明、卡西酮和甲基卡西酮等管制物质的每一个小分子变化都需要漫长的法律程序才能将新物质纳入管制物质法。在此过程中，我们认为公众健康受到了威胁。化学家和经销商找到了一种“合法”绕过“衍生法”的新方法，即销售一组名为“合成大麻素”的新物质。合成大麻素与大麻或哈希什中出现的四氢大麻酚（THC）的化学结构不同，但对身体的影响方式相同，并且根据文献记载，其效力要强五倍。合成大麻素在以色列以不同的别名出售，如：“马布苏顿”、“好人先生”、“香料”、“萨巴巴”和“柠檬草”。该物质可以通过不同方式使用，如吸烟、吸入或吞咽。使用合成大麻素会导致副作用，包括：欣快感、头晕、头痛、口渴、偏执、失眠、疲劳和视力障碍。以色列已有因使用这些物质而住院的病例报告。症状包括精神障碍。在2010年12月于以色列禁毒管理局举行的精神药物多部委委员会紧急会议上，决定建议卫生部长将一组全面的“合成大麻素”列入以色列的管制药物清单。2011年4月5日，在获得以色列议会卫生和福利委员会的批准后，对《危险药物条例》（新版本）——5732 - 1973进行了修订，增加了一组全面的“合成大麻素”。这些包括：JWH - 018、JWH - 133、JWH - 073、CP 47,497、CP 55,940、HU - 331、HU - 210、HU - 211、HU - 250。
