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[合成大麻素的作用与发生情况]

[Effect and occurrence of synthetic cannabinoids].

作者信息

Tuv Silja Skogstad, Strand Maren Cecilie, Karinen Ritva, Øiestad Elisabeth Leere, Christophersen Asbjørg S, Vindenes Vigdis

机构信息

Divisjon for rettsmedisin og rusmiddelforskning, Nasjonalt folkehelseinstitutt, Norway.

出版信息

Tidsskr Nor Laegeforen. 2012 Oct 30;132(20):2285-8. doi: 10.4045/tidsskr.12.0471.

DOI:10.4045/tidsskr.12.0471
PMID:23736196
Abstract

BACKGROUND

''Spice'' is the term used for various products that contain synthetic cannabinoids. In recent years a growing number of products have been reported on the illegal market, also in Norway. The substances are sold over the internet as 'legal' cannabis. A number of the substances have gradually been classified as narcotics, also in Norway, but new variants continue to be developed. An overview is provided here of current knowledge of the efficacy and occurrence of synthetic cannabinoids.

METHOD

The article is based on a discretionary selection of relevant articles found by means of a literature search in PubMed and on reports from Norwegian and European authorities and research institutions.

RESULTS

Synthetic cannabinoids are a large group of drugs of abuse that have an effect similar to cannabis, but may be considerably more potent. The contents of the various Spice products vary with respect to potency, purity and the number and types of additives, and this implies a risk of unintentional overdose. There are reports from abroad of cardiac infarction in teenagers, severe psychoses, anxiety, unconsciousness and deaths following use.

INTERPRETATION

Synthetic cannabinoids are marketed over the internet as legal and harmless cannabis, but can cause severe intoxication and death. There is a considerable need for more knowledge about the action and harmful effects of these substances.

摘要

背景

“香料”一词用于指代含有合成大麻素的各类产品。近年来,非法市场上此类产品不断增多,挪威也不例外。这些物质在互联网上作为“合法”大麻出售。在挪威,一些此类物质已逐渐被列为麻醉品,但新的变体仍在不断出现。本文概述了目前关于合成大麻素的功效及出现情况的知识。

方法

本文基于通过在PubMed上进行文献检索以及挪威和欧洲当局及研究机构的报告,自行挑选相关文章。

结果

合成大麻素是一大类滥用药物,其作用与大麻相似,但效力可能强得多。各类“香料”产品的成分在效力、纯度以及添加剂的数量和种类方面存在差异,这意味着存在意外过量服用的风险。国外有报告称青少年使用后出现心肌梗死、严重精神病、焦虑、昏迷及死亡情况。

解读

合成大麻素在互联网上作为合法且无害的大麻进行销售,但可导致严重中毒甚至死亡。对于这些物质的作用和有害影响,迫切需要更多了解。

相似文献

1
[Effect and occurrence of synthetic cannabinoids].[合成大麻素的作用与发生情况]
Tidsskr Nor Laegeforen. 2012 Oct 30;132(20):2285-8. doi: 10.4045/tidsskr.12.0471.
2
[Synthetic cannabinoids--the new "legal high" drugs].[合成大麻素——新型“合法兴奋剂”药物]
Harefuah. 2011 Dec;150(12):884-7, 937.
3
["Spice"--synthetic cannabinoids with dangerous effects].["香料"——具有危险作用的合成大麻素]
Lakartidningen. 2014 Nov 11;111(47):2105-7.
4
Top 10 Facts You Need to Know About Synthetic Cannabinoids: Not So Nice Spice.关于合成大麻素你需要了解的十大事实:并非那么美妙的香料。
Am J Med. 2016 Mar;129(3):240-4.e1. doi: 10.1016/j.amjmed.2015.10.008. Epub 2015 Oct 30.
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Emergence and properties of spice and bath salts: a medicinal chemistry perspective.“香料”和“浴盐”的出现及其特性:从药物化学角度看。
Life Sci. 2014 Feb 27;97(1):9-19. doi: 10.1016/j.lfs.2013.09.026. Epub 2013 Oct 7.
6
The Synthetic Cannabinoids Phenomenon.合成大麻素现象
Curr Pharm Des. 2016;22(42):6420-6425. doi: 10.2174/1381612822666160919093450.
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Spice drugs as a new trend: mode of action, identification and legislation.香料毒品作为一种新趋势:作用模式、鉴定和立法。
Toxicol Lett. 2010 Sep 1;197(3):157-62. doi: 10.1016/j.toxlet.2010.06.002. Epub 2010 Jun 8.
8
Spice/K2 drugs--more than innocent substitutes for marijuana.香料/ K2 毒品——不仅仅是大麻的无辜替代品。
Int J Neuropsychopharmacol. 2014 Mar;17(3):509-25. doi: 10.1017/S1461145713001247. Epub 2013 Oct 29.
9
Spice, bath salts, and the U.S. military: the emergence of synthetic cannabinoid receptor agonists and cathinones in the U.S. Armed Forces.香料、浴盐与美国军队:合成大麻素受体激动剂和卡西酮在美国武装部队中的出现。
Mil Med. 2012 Sep;177(9):1041-8. doi: 10.7205/milmed-d-12-00180.
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Designer Drug (DD) abuse in Poland; a review of the psychoactive and toxic properties of substances found from seizures of illegal drug products and the legal consequences thereof. Part 1--cannabinoids and cathinones.波兰的新型毒品滥用情况;对从非法毒品产品缉获物中发现的物质的精神活性和毒性特性及其法律后果的综述。第1部分——大麻素和卡西酮
Ann Agric Environ Med. 2012;19(4):857-70.

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Self-Reported Illicit Drug Use Among Norwegian University and College Students. Associations With Age, Gender, and Geography.挪威大学生自我报告的非法药物使用情况。与年龄、性别和地理位置的关联。
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