Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
Org Lett. 2012 Mar 16;14(6):1398-401. doi: 10.1021/ol300111m. Epub 2012 Feb 21.
An efficient N-heterocyclic carbene (NHC)-catalyzed internal redox reaction of alkynals that bear a γ leaving group has been developed. This process provides a new access to a range of allenoates in good yields. Preliminary results demonstrate that the enantioselective variant can also be achieved.
发展了一种炔醛中γ离去基团的高效 N-杂环卡宾（NHC）催化的内部氧化还原反应。该过程为一系列烯丙酸盐提供了良好收率的新途径。初步结果表明，该对映选择性变体也可以实现。
