Department of Radiology, Vanderbilt University Institute of Imaging Science (VUIIS), Nashville, Tennessee 37232, USA.
J Am Chem Soc. 2012 Mar 7;134(9):3957-60. doi: 10.1021/ja210639c. Epub 2012 Feb 28.
We demonstrate that potassium 1-(13)C-phosphoenolpyruvate becomes hyperpolarized potassium 1-(13)C-phospholactate with (13)C T(1) = 36 s after molecular hydrogenation by PASADENA (Parahydrogen and Synthesis Allows Dramatically Enhanced Nuclear Alignment). This proof-of-principle study was conducted with a fully protonated molecular precursor. (13)C was polarized to a level of 1%, corresponding to nearly 4000-fold sensitivity enhancement at 3 T. The relevant homo- and heteronuclear spin-spin couplings are reported.
我们证明，通过 PASADENA（ParaHydrogen 和 Synthesis Allows Dramatically Enhanced Nuclear Alignment，即氢化使核极化显著增强）分子加氢后，钾 1-(13)C-磷酸烯醇丙酮酸可转化为超极化的钾 1-(13)C-磷酸丙糖，(13)C T(1)为 36 秒。这项原理验证研究是使用完全质子化的分子前体进行的。(13)C 的极化水平达到 1%，在 3 T 时的灵敏度提高了近 4000 倍。报告了相关的同核和异核自旋-自旋耦合。
