Department of Dermatology, Kochi Medical School, Kochi University, Kochi, Japan.
J Dermatol. 2012 Mar;39(3):219-24. doi: 10.1111/j.1346-8138.2011.01458.x.
Psoriasis is an inflammatory disease with dynamic interactions between the immune system and the skin. Recent studies have demonstrated that the interleukin (IL)-23/T-helper (Th)17 cell axis plays an important role in the pathogenesis of psoriasis. Here, the biology and function of Th17 cells as well as the crucial role of IL-23 in the context of the Th17 cell-dependent chronic inflammation in psoriatic skins are reviewed. Recent study about the role of the IL-23/Th17 axis in the pathogenesis of psoriasis-like lesions in K5.Stat3C transgenic mice is also discussed. This model mouse for psoriasis not only verifies the therapeutic efficacies of biologics that specifically target the IL-23/Th17 axis, but also clarifies the pathogenesis of psoriasis.
银屑病是一种炎症性疾病，免疫系统和皮肤之间存在动态相互作用。最近的研究表明，白细胞介素（IL）-23/T 辅助（Th）17 细胞轴在银屑病发病机制中起重要作用。本文综述了 Th17 细胞的生物学和功能，以及 IL-23 在银屑病皮肤中 Th17 细胞依赖性慢性炎症中的关键作用。还讨论了 IL-23/Th17 轴在 K5.Stat3C 转基因小鼠银屑病样病变发病机制中的作用。这种银屑病模型小鼠不仅验证了专门针对 IL-23/Th17 轴的生物制剂的治疗效果，还阐明了银屑病的发病机制。
