Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, KSA.
Curr Top Med Chem. 2012;12(9):1072-92. doi: 10.2174/156802612800229233.
The use of current antiepileptic drugs has been questioned due to the nonselectivity of the drugs and the undesirable side effects posed by them. This led to an intensive investigation in this area worldwide during the past 10 years. There have been some significant outcomes and the findings are promising as far as drug efficacy and safety is concerned. This review covers the new anticonvulsant agents that have shown encouraging activities and less neurotoxicity. A detailed pharmacology and pathophysiology of different types of epilepsy is described here with the structural classification of most active agents. The new structural classes of compounds may prove as lead molecules and good candidates for the future investigations.
由于现有抗癫痫药物的非选择性和不良副作用，其应用受到了质疑。这促使过去 10 年间全球都在该领域展开了深入研究。目前已取得了一些重大成果，就药物疗效和安全性而言，这些发现令人鼓舞。本综述涵盖了具有令人鼓舞的活性和较低神经毒性的新型抗癫痫药物。本文详细描述了不同类型癫痫的药理学和病理生理学，以及大多数活性药物的结构分类。新型化合物结构类别可能成为先导分子和未来研究的良好候选药物。
