Department of Dermatology, University of Miami Miller School of Medicine, 9980 Central Park Boulevard North, Boca Raton, FL 33428, USA.
Dermatol Ther. 2011 Sep-Oct;24(5):471-6. doi: 10.1111/j.1529-8019.2012.01458.x.
Effective dermatologic therapy depends on both the active drug and the properties of the delivery system. A topical delivery system, or vehicle, is defined as the substance that carries a specific drug into contact with and through the skin. The challenge to topical drug delivery is the transport across the skin barrier. Depending on the delivery system, penetration of the active drug can be quite variable and this is largely due to the physiochemical properties of the constituent components of that vehicle. Selection of the appropriate drug delivery system will depend on the active, anatomic site of disease and patient preferences.
有效的皮肤科治疗取决于活性药物和给药系统的特性。局部给药系统或载体定义为携带特定药物并使其与皮肤接触并穿透皮肤的物质。局部药物输送的挑战在于穿过皮肤屏障的传输。根据给药系统的不同，活性药物的渗透情况可能会有很大差异，这主要是由于该载体的组成成分的物理化学性质所致。适当的药物输送系统的选择将取决于活性药物、疾病的解剖部位和患者的偏好。
