Myburgh Jeanri, Liebenberg Wilna, Willers Clarissa, Dube Admire, Gerber Minja
Centre of Excellence for Pharmaceutical Sciences (Pharmacen™), North-West University, Potchefstroom 2531, South Africa.
School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Cape Town 7535, South Africa.
Pharmaceutics. 2023 Oct 3;15(10):2413. doi: 10.3390/pharmaceutics15102413.
The aim was to assess the suitability of three nano-based transdermal drug delivery systems containing ibuprofen: a nano-emulsion, a nano-emulgel, and a colloidal suspension with ibuprofen-loaded nanoparticles. Understanding the transdermal delivery of ibuprofen using nano-based drug delivery systems can lead to more effective pain relief and improved patient compliance. Characterization tests assessed the suitability of the developed drug delivery systems. Membrane release and skin diffusion studies, along with tape stripping, were performed to determine drug release and skin permeation of ibuprofen. In vitro cytotoxicity studies on HaCaT cells were conducted using MTT and neutral red assays to evaluate the safety of the developed drug delivery systems. Characterization studies confirmed stable drug delivery systems with ideal properties for transdermal delivery. Membrane release studies demonstrated the successful release of ibuprofen. In vitro skin diffusion experiments and tape stripping, detecting ibuprofen in the receptor phase, stratum corneum-epidermis, and epidermis-dermis, indicating successful transdermal and topical delivery. The in vitro cytotoxicity studies observed only minor cytotoxic effects on HaCaT cells, indicating the safety of the developed drug delivery systems. The investigation demonstrated promising results for the transdermal delivery of ibuprofen using the developed drug delivery systems, which contributes to valuable insights that may lead to improved pain management strategies.
一种纳米乳剂、一种纳米乳凝胶和一种含载布洛芬纳米颗粒的胶体悬浮液。了解使用纳米基给药系统的布洛芬透皮给药情况，有助于实现更有效的疼痛缓解并提高患者的依从性。特性测试评估了所开发的给药系统的适用性。进行了膜释放和皮肤扩散研究以及胶带剥离实验，以确定布洛芬的药物释放和皮肤渗透情况。使用MTT和中性红试验对HaCaT细胞进行了体外细胞毒性研究，以评估所开发的给药系统的安全性。特性研究证实了具有理想透皮给药特性的稳定给药系统。膜释放研究表明布洛芬成功释放。体外皮肤扩散实验和胶带剥离实验在受体相、角质层-表皮和表皮-真皮中检测到了布洛芬，表明透皮给药和局部给药成功。体外细胞毒性研究仅观察到对HaCaT细胞的轻微细胞毒性作用，表明所开发的给药系统是安全的。该研究表明，使用所开发的给药系统进行布洛芬透皮给药具有有前景的结果，这有助于获得宝贵的见解，可能会带来改进的疼痛管理策略。
