Neurology Department, Hospital de Braga, Braga, Portugal.
Psychiatry Clin Neurosci. 2012 Mar;66(2):153-6. doi: 10.1111/j.1440-1819.2011.02308.x.
Antibodies against N-methyl-D-aspartate receptor (NMDAR) are identified in the form of immune-mediated encephalitis in which typical manifestations include neuropsychiatric symptoms, seizures, abnormal movements, dysautonomia and hypoventilation. The authors report two cases of anti-NMDAR encephalitis with different presentations and patterns of progression. The first patient presented with status epilepticus and later developed psychosis, pyramidal signs and diffuse encephalopathy. The second patient presented with acute psychosis followed a week later by seizures, dystonia, rigidity, oromandibular dyskinesias and dysautonomia. Possible mechanisms responsible for the clinical manifestations of this disease are discussed in light of recently described additional clinical and laboratory findings.
抗 N-甲基-D-天冬氨酸受体（NMDAR）抗体在免疫介导性脑炎中表现为特征性的神经精神症状、癫痫发作、异常运动、自主神经功能障碍和通气不足。作者报告了两例具有不同表现和进展模式的抗 NMDAR 脑炎。第一例患者表现为癫痫持续状态，随后出现精神症状、锥体束征和弥漫性脑病。第二例患者表现为急性精神症状，一周后出现癫痫发作、肌张力障碍、僵硬、口面运动障碍和自主神经功能障碍。根据最近描述的其他临床和实验室发现，讨论了导致这种疾病临床表现的可能机制。
