Hashimoto S, Ohkawa T, Takekawa Y, Horiuchi J, Mori T, Amino S, Morita K, Tanaka Y, Mochizuki Y, Yanagisawa T
Department of Radiology, Keio University School of Medicine.
Nihon Igaku Hoshasen Gakkai Zasshi. 1990 Aug 25;50(8):993-1006.
The clinical usefulness of Z-100 (Z group) for the treatment of leukopenia caused by radiotherapy for malignant tumors was evaluated by comparing it with that of L-cysteine (L group) by the double-blind method. For 178 complete cases, there were no significant differences in the time-course of the WBC during radiotherapy between the two group. However, for cases with a large field of irradiation (15 X 15 cm = 225 cm2), the mean WBC count in the L group decreased more than that in the Z group. The Z group showed comparable or superior efficacy for the treatment of leukopenia in the L group although there were no significant differences. Adverse reactions were observed in 5.66% and 2.94% in the Z and L groups, respectively, without any significant difference between the groups. The utility rate, useful or better, was 73.9% and 69.2% in the Z and L groups, respectively, showing a slightly higher rate in the Z group than in the L group, although the difference between the two groups was not significant. These results confirmed that Z-100 has comparable or superior efficacy to L-cysteine for the treatment of leukopenia caused by large field radiotherapy for malignant tumors.
通过双盲法将Z - 100（Z组）与L - 半胱氨酸（L组）进行比较，评估Z - 100治疗恶性肿瘤放疗所致白细胞减少症的临床效用。对于178例完整病例，两组放疗期间白细胞的时间进程无显著差异。然而，对于照射野较大（15×15 cm = 225 cm²）的病例，L组的平均白细胞计数下降幅度大于Z组。尽管无显著差异，但Z组在治疗L组白细胞减少症方面显示出相当或更优的疗效。Z组和L组的不良反应发生率分别为5.66%和2.94%，两组间无显著差异。Z组和L组的有效率（有效或更佳）分别为73.9%和69.2%，Z组略高于L组，尽管两组间差异不显著。这些结果证实，对于治疗恶性肿瘤大野放疗所致白细胞减少症，Z - 100与L - 半胱氨酸具有相当或更优的疗效。
