Hashimoto S, Yanagisawa T, Mochizuki S, Ohkawa T, Amino S, Horiuchi J, Kamata R, Mori T, Tanaka Y, Takekawa Y
Department of Radiology, School of Medicine, Keio University.
Rinsho Hoshasen. 1990 Jun;35(6):709-14.
The clinical efficacy of Z-100 for the treatment of leukopenia caused by radiotherapy for malignant tumors was evaluated in an early clinical study using three doses, 2, 10 and 20 micrograms. According to the evaluation by investigators and time-course of WBC, the highest effective rate was achieved by 20 micrograms. Adverse reactions occurred in all groups, but there were no serious or clinically relevant reactions. These results suggested that Z-100 is clinically useful for the treatment of leukopenia caused by radiotherapy.
在一项早期临床研究中，使用2微克、10微克和20微克三种剂量评估了Z-100治疗恶性肿瘤放疗引起的白细胞减少症的临床疗效。根据研究者的评估和白细胞的时间进程，20微克剂量的有效率最高。所有组均出现不良反应，但无严重或临床相关反应。这些结果表明，Z-100在临床上可用于治疗放疗引起的白细胞减少症。
