Falix Farah A, Aronson Daniël C, Lamers Wouter H, Gaemers Ingrid C
Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.
Biochim Biophys Acta. 2012 Jun;1822(6):988-95. doi: 10.1016/j.bbadis.2012.02.003. Epub 2012 Feb 12.
The Delta-Notch pathway is an evolutionarily conserved signaling pathway which controls a broad range of developmental processes including cell fate determination, terminal differentiation and proliferation. In mammals, four Notch receptors (NOTCH1-4) and five activating canonical ligands (JAGGED1, JAGGED2, DLL1, DLL3 and DLL4) have been described. The precise function of noncanonical Notch ligands remains unclear. Delta-like 1 homolog (DLK1), the best studied noncanonical Notch ligand, has been shown to act as an inhibitor of Notch signaling in vitro, but its function in vivo is poorly understood. In this review we summarize Notch signaling during development and highlight recent studies in DLK1expression that reveal new insights into its function.
Delta-Notch信号通路是一条在进化上保守的信号通路,它控制着广泛的发育过程,包括细胞命运决定、终末分化和增殖。在哺乳动物中,已描述了四种Notch受体(NOTCH1-4)和五种激活的经典配体(JAGGED1、JAGGED2、DLL1、DLL3和DLL4)。非经典Notch配体的确切功能尚不清楚。Delta样1同源物(DLK1)是研究得最深入的非经典Notch配体,已证明它在体外作为Notch信号的抑制剂起作用,但其在体内的功能却知之甚少。在这篇综述中,我们总结了发育过程中的Notch信号,并重点介绍了关于DLK1表达的最新研究,这些研究揭示了对其功能的新见解。