Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Göteborg, Sweden.
Cancer Lett. 2012 Dec 31;327(1-2):90-6. doi: 10.1016/j.canlet.2012.02.013. Epub 2012 Feb 18.
Endogenous processes or genotoxic agents can induce many types of single DNA damage (single-strand breaks, oxidized bases and abasic sites). In addition, ionizing radiation induces complex lesions such as double-strand breaks and clustered damage. To preserve the genomic stability and prevent carcinogenesis, distinct repair pathways have evolved. Despite this, complex DNA damage can cause severe problems and is believed to contribute to the biological consequences observed in cells exposed to genotoxic stress. In this review, the current knowledge of formation and repair of complex DNA damage is summarized and the risks and biological consequences associated with their repair are discussed.
内源性过程或遗传毒性剂可诱导多种类型的单链 DNA 损伤（单链断裂、氧化碱基和无碱基位点）。此外，电离辐射还会诱导双链断裂和聚集性损伤等复杂损伤。为了保持基因组稳定性和防止癌变，已经进化出了不同的修复途径。尽管如此，复杂的 DNA 损伤仍可能会导致严重的问题，并被认为与遗传毒性应激下细胞中观察到的生物学后果有关。在这篇综述中，总结了目前对复杂 DNA 损伤的形成和修复的认识，并讨论了与它们的修复相关的风险和生物学后果。
