Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.
Cancer Lett. 2012 Dec 31;327(1-2):3-4. doi: 10.1016/j.canlet.2012.03.032. Epub 2012 Apr 3.
The production of a plethora of reactive oxygen and nitrogen species in the cell and tissues as the result of endogenous or exogenous mechanisms and interaction of our cells with the environment define the so called 'oxidative load'. The final balance between the oxidatively-induced stress and the various cellular defense mechanisms draw the picture on the landscape of oxidative injury and biological consequences. In this Special Issue, I have compiled a synthesis of concise reviews by leading experts in their fields. The articles focus on the current status and advances in the various pathways leading to the production of high oxidative stress, DNA damage and its processing in human cells and tissues. Significant mechanistic insights are offered as well as connections with biological and clinical significance.
细胞和组织中过多的活性氧和氮物种的产生是内源性或外源性机制的结果，也是我们的细胞与环境相互作用的结果，这定义了所谓的“氧化应激”。氧化诱导的应激与各种细胞防御机制之间的最终平衡描绘了氧化损伤和生物学后果的图景。在本期特刊中，我汇集了该领域的领先专家撰写的简明综述。这些文章重点介绍了导致人类细胞和组织中产生高氧化应激、DNA 损伤及其处理的各种途径的现状和进展。还提供了重要的机制见解以及与生物学和临床意义的联系。
