Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Korea.
Org Biomol Chem. 2012 Apr 7;10(13):2692-8. doi: 10.1039/c2ob07137a. Epub 2012 Feb 22.
A Pd-catalyzed direct cross-coupling of 3-bromocoumarins with heteroarenes provided an efficient route to synthesizing 3-heteroarylcoumarins. The reaction scope for the transformation was fairly broad, affording modest to good yields of various 3-heteroarylcoumarin scaffolds, which are privileged structures and prevalent motifs in many biologically active compounds and fluorophores.
钯催化的 3-溴香豆素与杂芳烃的直接交叉偶联为合成 3-杂芳基香豆素提供了一种有效的方法。该转化的反应范围相当广泛，能够以中等至良好的收率得到各种 3-杂芳基香豆素骨架，这些骨架是许多生物活性化合物和荧光团中的重要结构和常见基序。
