Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ophthalmologica. 2012;227(4):223-32. doi: 10.1159/000335628. Epub 2012 Feb 21.
To investigate the association between diabetic retinopathy (DR) in type 2 diabetes mellitus and three polymorphisms of the receptor for advanced glycation end products (RAGE) gene, -429T/C, -374T/A and Gly82Ser.
A literature search was conducted through PubMed and Web of Science (up to August 31, 2011). Pooled odds ratios (ORs) were estimated using fixed-effects (FE) and random-effects (RE) models in co-dominant, recessive and dominant models. A sensitivity analysis was performed by excluding invalid studies.
Six articles investigated the -429T/C polymorphism, 7 publications were associated with the -374T/A polymorphism and 5 studies were associated with Gly82Ser in DR. For the -429T/C variant, we found no significant difference between DR patients and those with diabetes without retinopathy. A significant association of allele A with DR was found in the recessive model for the -374T/A variant (RE OR = 0.64, 95% CI = 0.42-0.99, p = 0.05, p heterogeneity = 0.55). In the recessive and co-dominant models for the Gly82Ser polymorphism, the pooled ORs were positive in the fixed-effects model (FE OR = 2.89, 95% CI = 1.49-5.60, p = 0.002, p heterogeneity = 0.20; and FE OR = 3.45, 95% CI = 1.76-6.67, p = 0.0003, p heterogeneity = 0.07, respectively), but in the random-effects model the results were negative.
Our research confirmed an association between the RAGE -374T/A polymorphism and retinopathy in subjects with type 2 diabetes and the -374AA allele was found to be a protective factor for type 2 diabetes. Otherwise, the RAGE Gly82Ser polymorphism might be considered a significant risk for DR in Asian populations.
研究 2 型糖尿病患者中晚期糖基化终产物受体（RAGE）基因的 -429T/C、-374T/A 和 Gly82Ser 三个多态性与糖尿病性视网膜病变（DR）之间的关联。
通过 PubMed 和 Web of Science（截至 2011 年 8 月 31 日）进行文献检索。采用固定效应（FE）和随机效应（RE）模型，在共显性、隐性和显性模型中估计合并优势比（OR）。通过排除无效研究进行敏感性分析。
有 6 篇文章研究了 -429T/C 多态性，7 篇文章与 -374T/A 多态性相关，5 篇文章与 Gly82Ser 在 DR 中的多态性相关。对于 -429T/C 变体，我们发现 DR 患者与无视网膜病变的糖尿病患者之间没有显著差异。在 -374T/A 变体的隐性模型中，等位基因 A 与 DR 显著相关（RE OR = 0.64，95%CI = 0.42-0.99，p = 0.05，p 异质性 = 0.55）。在 Gly82Ser 多态性的隐性和共显性模型中，固定效应模型中的合并 OR 为阳性（FE OR = 2.89，95%CI = 1.49-5.60，p = 0.002，p 异质性 = 0.20；FE OR = 3.45，95%CI = 1.76-6.67，p = 0.0003，p 异质性 = 0.07），但在随机效应模型中结果为阴性。
我们的研究证实 RAGE-374T/A 多态性与 2 型糖尿病患者的视网膜病变之间存在关联，并且发现 374AA 等位基因是 2 型糖尿病的保护因素。否则，RAGE Gly82Ser 多态性可能被认为是亚洲人群 DR 的一个重要危险因素。
