晚期糖基化终末产物受体（RAGE）-374T/A基因多态性与2型糖尿病患者糖尿病视网膜病变的关联

Association between the RAGE (receptor for advanced glycation end-products) -374T/A gene polymorphism and diabetic retinopathy in T2DM.

作者信息

Tao Dan, Mai Xuancheng, Zhang Tiesong, Mei Yan

机构信息

Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, China.

Kunming Children's Hospital, Kunming, China.

出版信息

Rev Assoc Med Bras (1992). 2017 Nov;63(11):971-977. doi: 10.1590/1806-9282.63.11.971.

DOI:10.1590/1806-9282.63.11.971

PMID:29451661

Abstract

OBJECTIVE

Interaction between advanced glycation end-products (AGEs) and receptor for AGEs (RAGE) in cells could affect both extracellular and intracellular structure and function, which plays a pivotal role in diabetic microvascular complications. The results from previous epidemiological studies on the association between RAGE gene -374T/A polymorphism and diabetic retinopathy (DR) risk were inconsistent. Thus, we conducted this meta-analysis to summarize the possible association between RAGE -374T/A polymorphism and DR risk.

METHOD

We searched all relevant articles on the association between RAGE -374T/A polymorphism and DR risk from PubMed, Cochrane Library, ScienceDirect, Wanfang, VIP and Chinese National Knowledge Infrastructure (CNKI) web databases up to August 2016. Odds ratio (OR) with 95% confidence interval (CI) were calculated to assess those associations. All analyses were performed using the Review Manager software.

RESULTS

Nine case-control studies, including 1,705 DR cases and 2,236 controls were enrolled, and the results showed that the A allele of RAGE -374T/A polymorphism was significantly associated with increased DR risk in dominant model (TA/AA vs. TT: OR=1.22, 95CI 1.05-1.41, p=0.006) and heterozygote model (TA vs. TT: OR=1.26, 95CI 1.07-1.47, p=0.005). The subgroup analysis by ethnicity showed that significantly increased DR risk was found in both Asian and Caucasian populations.

CONCLUSION

This meta-analysis reveals that the A allele of RAGE -374T/A polymorphism probably increase DR risk.

摘要

目的

细胞内晚期糖基化终产物（AGEs）与AGEs受体（RAGE）之间的相互作用会影响细胞外和细胞内的结构与功能，这在糖尿病微血管并发症中起关键作用。先前关于RAGE基因-374T/A多态性与糖尿病视网膜病变（DR）风险之间关联的流行病学研究结果并不一致。因此，我们进行了这项荟萃分析，以总结RAGE -374T/A多态性与DR风险之间可能存在的关联。

方法

我们检索了截至2016年8月在PubMed、Cochrane图书馆、ScienceDirect、万方、维普和中国知网（CNKI）网络数据库中所有关于RAGE -374T/A多态性与DR风险关联的相关文章。计算比值比（OR）及其95%置信区间（CI）来评估这些关联。所有分析均使用Review Manager软件进行。

结果

纳入了9项病例对照研究，包括1705例DR病例和2236例对照，结果显示，在显性模型（TA/AA vs. TT：OR = 1.22，95%CI 1.05 - 1.41，p = 0.006）和杂合子模型（TA vs. TT：OR = 1.26，95%CI 1.07 - 1.47，p = 0.005）中，RAGE -374T/A多态性的A等位基因与DR风险增加显著相关。按种族进行的亚组分析表明，亚洲和白种人群中DR风险均显著增加。