Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Mucosal Immunol. 2012 May;5(3):240-7. doi: 10.1038/mi.2012.6. Epub 2012 Feb 22.
The hypothesis of helper T (T(h))1/T(h)2 cytokine balance proposed by Mosmann and Coffman is often invoked to explain the development of inflammatory diseases, including inflammatory bowel diseases (IBD). Recently, however, a newly identified class of T(h) cells-T(h)17 cells, which produce T(h)17 family cytokines-has been recognized as an essential subpopulation in the development of almost all kinds of human and animal inflammatory diseases, rather than T(h)1 and T(h)2 cells. A representative T(h)17 family cytokine, interleukin (IL)-17A, is produced by not only T(h)17 cells, but also by other types of cells, such as T-cell receptor γδ T cells, natural killer (NK) T cells, NK cells, myeloid cells, and innate lymphoid cells, which may also be critically involved in the initiation and persistence of IBD. Here we review recent advances in the study of such IL-17A-producing cells in the pathogenesis of IBD.
莫斯曼和科夫曼提出的辅助性 T（T(h)）1/T(h)2 细胞因子平衡假说经常被用来解释炎症性疾病的发展，包括炎症性肠病（IBD）。然而，最近新发现的一类 T(h)细胞——T(h)17 细胞，其产生 T(h)17 细胞因子家族，被认为是几乎所有类型的人类和动物炎症性疾病发展的必需亚群，而不是 T(h)1 和 T(h)2 细胞。白细胞介素（IL）-17A 是 T(h)17 细胞产生的一种代表性 T(h)17 细胞因子，也由其他类型的细胞产生，如 T 细胞受体 γδ T 细胞、自然杀伤（NK）T 细胞、NK 细胞、髓样细胞和固有淋巴细胞，这些细胞可能也在 IBD 的启动和持续中起关键作用。在这里，我们综述了最近在 IBD 发病机制中研究这类产生 IL-17A 的细胞的进展。
