Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Nat Immunol. 2017 May 18;18(6):604-611. doi: 10.1038/ni.3726.
Shortly after the discovery of interleukin 17 (IL-17)-producing CD4 helper T cells (T17 cells), it was found that γδ T cells can also secrete large amounts of this pro-inflammatory cytokine. A decade later, it is now known that IL-17 γδ T cells (γδ17 T cells) are often the main providers of IL-17A in various models of inflammatory diseases, while they also contribute to protective immune responses to infectious organisms. Due to an intricate thymic program of differentiation, γδ17 T cells are able to respond faster than T17 cells do and thus predominate in the early stages of inflammatory responses. Here we review the current knowledge of the development, activation and pathophysiological functions of γδ17 T cells, aiming to increase the awareness in the community of the therapeutic potential of this 'other side' of IL-17-mediated immune responses.
在发现产生白细胞介素 17（IL-17）的辅助性 CD4 阳性 T 细胞（T17 细胞）后不久，人们发现 γδ T 细胞也可以大量分泌这种促炎细胞因子。十年后，现在人们已经知道，IL-17γδ T 细胞（γδ17 T 细胞）通常是各种炎症性疾病模型中 IL-17A 的主要提供者，同时它们也有助于对感染病原体的保护性免疫反应。由于复杂的胸腺分化程序，γδ17 T 细胞能够比 T17 细胞更快地做出反应，因此在炎症反应的早期阶段占主导地位。在这里，我们综述了 γδ17 T 细胞的发育、激活和病理生理学功能的最新知识，旨在提高人们对这种 IL-17 介导的免疫反应“另一面”的治疗潜力的认识。
