Department of Orthopaedic Surgery, Toho University School of Medicine, Tokyo, Japan.
Mod Rheumatol. 2012 Nov;22(6):844-8. doi: 10.1007/s10165-012-0612-2. Epub 2012 Feb 23.
We retrospectively investigated the influence of biological agents on delayed wound healing and the occurrence of postoperative surgical site infection (SSI) in patients after surgery for rheumatoid arthritis. The patients were divided into two groups-those with and without treatment with biological agents (276 and 278 joints, respectively)-and adverse events (delay in wound healing and SSI) were investigated. Wound healing was delayed in 11.4% of total knee arthroplasty (TKA) operations, 16.7% of total ankle arthroplasty operations, and 9.7% of foot surgeries in the treatment group, and in 5.5% of TKA operations, 12.5% of total elbow arthroplasty operations, and 5.7% of foot surgeries in the non-treatment group. The difference in the incidence of delayed wound healing between the two groups was not statistically significant. In the treatment group, postoperative superficial and deep infection developed in one and two joints, respectively. In the non-treatment group, superficial infection developed in one joint. There was no statistically significant difference between the two groups. These findings suggest that the use of biological agents may not affect the incidence of postoperative adverse events related to wound healing and SSI.
我们回顾性研究了生物制剂对类风湿关节炎手术后患者伤口愈合延迟和术后手术部位感染（SSI）发生的影响。将患者分为两组-使用生物制剂治疗组（276 个关节）和未使用生物制剂治疗组（278 个关节），并对不良事件（伤口愈合延迟和 SSI）进行了调查。在治疗组中，全膝关节置换术（TKA）手术、全踝关节置换术和足部手术的伤口愈合延迟发生率分别为 11.4%、16.7%和 9.7%，而在未治疗组中，TKA 手术、全肘置换术和足部手术的伤口愈合延迟发生率分别为 5.5%、12.5%和 5.7%。两组之间伤口愈合延迟的发生率差异无统计学意义。在治疗组中，术后发生 1 例浅表感染和 2 例深部感染。在未治疗组中，1 个关节发生浅表感染。两组之间无统计学差异。这些发现表明，使用生物制剂可能不会影响与伤口愈合和 SSI 相关的术后不良事件的发生率。
