Kubota Ayako, Sekiguchi Masayuki, Nakamura Takashi, Miyazaki Yoshiyasu, Suguro Toru
Department of Orthopaedic Surgery, School of Medicine, Faculty of Medicine, Toho Univiersity , Tokyo , Japan.
Mod Rheumatol. 2014 May;24(3):430-3. doi: 10.3109/14397595.2013.844387. Epub 2013 Oct 21.
The goal of the study was to examine the influence of biological agents on postoperative infections such as surgical site infection (SSI) and late infection in patients with rheumatoid arthritis after total joint arthroplasty at our hospital between January 2006 and December 2011.
The patients were divided into groups with (Bio group, 267 joints) and without (Non-Bio group, 300 joints) treatment with biological agents. We examined the incidence of postoperative infection in Bio group and Non-Bio group. Multivariate logistic regression analysis was performed to identify the risk factor of postoperative infection.
The incidences of superficial and deep SSI were 0.37% and 1.0%, respectively, in the Bio group, and 0.67% and 0%, respectively, in the Non-Bio group, with no significant difference between the two groups. The incidences of late infection were 1.0% and 0% in the Bio and Non-Bio groups, respectively, again with no significant difference between the groups. Multivariate logistic regression analysis revealed the following values for the surgery of the foot and ankle region [P = 0.001, odds ratio (OR) = 19.27; 95% confidence interval (CI) 4.67-79.45]. The use of biological agents was not a risk factor for postoperative infection.
These results suggest that the use of biological agents does not significantly increase the incidences of SSI and late infection after orthopedic surgery in patients with rheumatoid arthritis after total joint arthroplasty.
本研究的目的是探讨生物制剂对2006年1月至2011年12月期间在我院接受全关节置换术的类风湿关节炎患者术后感染的影响，如手术部位感染（SSI）和晚期感染。
将患者分为接受生物制剂治疗的组（生物制剂组，267个关节）和未接受生物制剂治疗的组（非生物制剂组，300个关节）。我们检查了生物制剂组和非生物制剂组术后感染的发生率。进行多因素logistic回归分析以确定术后感染的危险因素。
生物制剂组浅表和深部SSI的发生率分别为0.37%和1.0%，非生物制剂组分别为0.67%和0%，两组之间无显著差异。生物制剂组和非生物制剂组晚期感染的发生率分别为1.0%和0%，两组之间同样无显著差异。多因素logistic回归分析显示足踝区域手术的以下数值[P = 0.001，比值比（OR）= 19.27；95%置信区间（CI）4.67 - 79.45]。使用生物制剂不是术后感染的危险因素。
这些结果表明，在类风湿关节炎患者全关节置换术后，使用生物制剂不会显著增加骨科手术后SSI和晚期感染的发生率。
