Department of Community Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.
Cancer Epidemiol Biomarkers Prev. 2012 May;21(5):701-4. doi: 10.1158/1055-9965.EPI-12-0015. Epub 2012 Feb 21.
Incidence of cancer in children has increased in recent decades, and known risk factors can account for only a small minority of cases. Gestation and early childhood are particularly vulnerable periods in human development and an important aspect of development is in circadian rhythmicity. Emerging evidence implicates the molecular circadian mechanism in a vast array of other physiologic functions including metabolism, DNA damage response and cell-cycle regulation. Electric light exposure at night can disrupt circadian rhythms and, thereby, many other physiologic processes that are under circadian control. On this basis, it is proposed that ill-timed electric light exposure to pregnant women, to neonates, infants, and small children may increase cancer risk in those children. There are practical implications and interventions that accrue from this idea should it later be confirmed to be true.
近年来,儿童癌症的发病率有所增加,已知的风险因素只能解释一小部分病例。妊娠和幼儿期是人发育过程中特别脆弱的时期,而发育的一个重要方面就是昼夜节律。新出现的证据表明,分子昼夜节律机制与包括代谢、DNA 损伤反应和细胞周期调节在内的许多其他生理功能有关。夜间的电灯照射会破坏昼夜节律,从而破坏许多其他受昼夜节律控制的生理过程。基于此,有人提出,孕妇、新生儿、婴儿和幼儿在不合适的时候接触电灯可能会增加这些儿童的癌症风险。如果这一观点后来被证实是正确的,那么就会产生实际影响和干预措施。