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Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle.
Nat Struct Biol. 2002 Dec;9(12):950-7. doi: 10.1038/nsb872.
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Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission.
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D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP.
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Crystal Structure and Biochemical Characterization of a Mycobacterium smegmatis AAA-Type Nucleoside Triphosphatase Phosphohydrolase (Msm0858).
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Conformational changes in the AAA ATPase p97-p47 adaptor complex.
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Nucleotide dependent motion and mechanism of action of p97/VCP.
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Nucleotide-dependent conformational changes of the AAA+ ATPase p97 revisited.
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Molecular Mechanisms Driving and Regulating the AAA+ ATPase VCP/p97, an Important Therapeutic Target for Treating Cancer, Neurological and Infectious Diseases.
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Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition.
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Communication network within the essential AAA-ATPase Rix7 drives ribosome assembly.
PNAS Nexus. 2022 Jul 21;1(4):pgac118. doi: 10.1093/pnasnexus/pgac118. eCollection 2022 Sep.
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Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state.
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Conserved L464 in p97 D1-D2 linker is critical for p97 cofactor regulated ATPase activity.
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Shaping the Nascent Ribosome: AAA-ATPases in Eukaryotic Ribosome Biogenesis.
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Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy.
Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4380-E4388. doi: 10.1073/pnas.1706205114. Epub 2017 May 16.
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Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex.
Cell. 2017 May 4;169(4):722-735.e9. doi: 10.1016/j.cell.2017.04.020.
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The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97.
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1
Cellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding.
Mol Cell Biol. 2011 Apr;31(7):1528-39. doi: 10.1128/MCB.00962-10. Epub 2011 Jan 31.
2
The complexities of p97 function in health and disease.
Mol Biosyst. 2011 Mar;7(3):700-10. doi: 10.1039/c0mb00176g. Epub 2010 Dec 14.
3
Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation.
J Neurosci. 2010 Apr 28;30(17):6132-42. doi: 10.1523/JNEUROSCI.5874-09.2010.
4
New ATPase regulators--p97 goes to the PUB.
Int J Biochem Cell Biol. 2009 Dec;41(12):2380-8. doi: 10.1016/j.biocel.2009.05.017. Epub 2009 Jun 2.
5
Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change.
Structure. 2008 May;16(5):715-26. doi: 10.1016/j.str.2008.02.010.
6
Role(s) of Cdc48/p97 in mitosis.
Biochem Soc Trans. 2008 Feb;36(Pt 1):126-30. doi: 10.1042/BST0360126.
7
Ubiquitin receptors and ERAD: a network of pathways to the proteasome.
Semin Cell Dev Biol. 2007 Dec;18(6):780-91. doi: 10.1016/j.semcdb.2007.09.008. Epub 2007 Sep 8.
8
Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation.
Proc Natl Acad Sci U S A. 2007 May 22;104(21):8785-90. doi: 10.1073/pnas.0702966104. Epub 2007 May 11.
9
Central pore residues mediate the p97/VCP activity required for ERAD.
Mol Cell. 2006 May 19;22(4):451-62. doi: 10.1016/j.molcel.2006.03.036.
10
The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor.
Proc Natl Acad Sci U S A. 2006 May 30;103(22):8348-53. doi: 10.1073/pnas.0602747103. Epub 2006 May 18.
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