Meyer Hemmo, Popp Oliver
Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland.
Biochem Soc Trans. 2008 Feb;36(Pt 1):126-30. doi: 10.1042/BST0360126.
The ubiquitin-dependent chaperone Cdc48 (cell division cycle 48)/p97 is involved in a variety of degradative and regulatory processes during interphase that help to maintain cellular homoeostasis. The results available so far suggest that its basic activity is to mobilize ubiquitinated substrate proteins from cellular structures or segregate them from binding partners, and then hand them over for degradation or recycling. Several studies in different organisms show that Cdc48/p97 also has critical roles in mitosis. However, many important aspects of these functions and the general perspective have remained unclear.
泛素依赖性伴侣蛋白Cdc48（细胞分裂周期48）/p97参与间期的多种降解和调节过程，有助于维持细胞内稳态。目前可得的结果表明，其基本活性是从细胞结构中动员泛素化的底物蛋白，或将它们与结合伴侣分离，然后将其送去降解或回收利用。在不同生物体中的多项研究表明，Cdc48/p97在有丝分裂中也起着关键作用。然而，这些功能的许多重要方面以及总体情况仍不清楚。
