Yildirim Gökhan, Sayin Refah, Cögen Etem Emre, Odabas Faruk Omer, Tombul Temel
Yuzuncu Yil University, Faculty of Medicine, Department of Neurology, Van, Turkey.
J Pak Med Assoc. 2011 Oct;61(10):978-82.
To investigate the latencies, amplitudes of R1, R2i and R2k responses and R2 habituation; to compare the groups with each other and with the placebo group and to demonstrate new evidences on migraine and tension-type headache TTH mechanisms.
This analytical study was carried out among 40 migraine patients who were admitted to Yuzuncu Yil University, Medical Faculty, Neurology Clinics between May 2009 and December 2009, with or without aura according to the diagnostic criteria of International Headache Society 2004 classification. Forty TTH patients, who were diagnosed with TTH were included, and 40 control group subjects were formed according to the same demographic data. SPSSv13 was used for Chi-square test, one-way ANOVA and Pearson correlation coefficients was used for the determination of the relation between the groups and categorical.
Mean age was 33.04 +/- 9.07 years. An average of RR2k latency was significantly high in migraine group comparing with TTH and the control groups, and in TTH group comparing with the control group. Similarly, the average of LR2k latency was found to be significantly higher in migraine group than TTH and the control groups, and significantly higher in TTH group than the control group.
Our findings demonstrated that brainstem and trigeminovascular connections play an important role in migraine pathogenesis and that central mechanisms play a role in TTH and concerning these two diseases.
研究R1、R2i和R2k反应的潜伏期、波幅以及R2习惯化；对各研究组之间以及与安慰剂组进行比较，并展示偏头痛和紧张型头痛（TTH）机制的新证据。
本分析性研究纳入了2009年5月至2009年12月期间入住于约兹加特博阿齐奇大学医学院神经科门诊的40例偏头痛患者，根据2004年国际头痛协会分类诊断标准，这些患者有无先兆均可。纳入了40例被诊断为TTH的患者，并根据相同的人口统计学数据组成40例对照组。使用SPSSv13进行卡方检验、单因素方差分析，并使用Pearson相关系数来确定组间关系和分类情况。
平均年龄为33.04±9.07岁。与TTH组和对照组相比，偏头痛组RR2k潜伏期平均值显著较高，与对照组相比，TTH组RR2k潜伏期平均值也显著较高。同样，偏头痛组LR2k潜伏期平均值高于TTH组和对照组，TTH组LR2k潜伏期平均值也显著高于对照组。
我们的研究结果表明，脑干和三叉神经血管连接在偏头痛发病机制中起重要作用，中枢机制在TTH以及这两种疾病中起作用。
