Avramidis Theodoros, Bougea Anastasia, Hadjigeorgiou George, Thomaides Thomas, Papadimitriou Alexandros
Headache Department, Red Cross Hospital, Athens, Greece.
First Department of Neurology, Aeginition Hospital, Medical School, National and Kapodistrian University, 72-74 Vasilissis Sofias Avenue, 11528, Athens, Greece.
Neurol Sci. 2017 Jun;38(6):993-998. doi: 10.1007/s10072-017-2885-x. Epub 2017 Mar 8.
ΑBSTRACT: R1 and R2 blink reflex latencies were investigated blind in 55 patients with chronic tension-type headache, 55 patients with migraine, and 55 headache-free controls. Standard electrical stimulation of the supraorbital nerve was applied and the response was recorded from the ipsilateral orbicularis oculi muscles. There were no R1 or R2 latency differences between the three groups. During migraine attacks we observed a statistically significant reduction of R2 amplitude and area. The main finding of our study was the elicitation of the late R2" response at different interstimulus intervals in migraine patients compared to the tension-type headache and control groups. This could be considered an indication of habituation mechanism hyperexcitability, although further investigation is needed to confirm these findings and establish the neurophysiologic basis. This study suggests that blink reflex studies can be used routinely as a non-evasive and inexpensive method for the evaluation of headache patients.
对55例慢性紧张型头痛患者、55例偏头痛患者及55例无头痛的对照者进行了R1和R2眨眼反射潜伏期的盲法研究。采用标准电刺激眶上神经，并记录同侧眼轮匝肌的反应。三组之间R1或R2潜伏期无差异。在偏头痛发作期间，我们观察到R2波幅和面积有统计学意义的降低。本研究的主要发现是，与紧张型头痛组和对照组相比，偏头痛患者在不同的刺激间隔下诱发了晚期R2”反应。这可被认为是习惯化机制过度兴奋的一个指标，尽管需要进一步研究来证实这些发现并建立神经生理学基础。本研究表明，眨眼反射研究可作为一种无创且廉价的方法常规用于评估头痛患者。
