Department of Dermatology and Allergy, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Br J Dermatol. 2012 Jun;166(6):1295-300. doi: 10.1111/j.1365-2133.2012.10896.x.
Primary cutaneous lymphomas (CLs) are a heterogeneous group of diseases arising from B or T lymphocytes. CLs are grouped according to their clinical behaviour into indolent, intermediate and aggressive types. Indolent CLs respond well to therapy but frequently relapse, resulting in prolonged periods of follow-up.
To evaluate the outcome of follow-up examinations in indolent CL.
We retrospectively analysed a cohort from a CL outpatient clinic at a tertiary referral centre. Seventy-five patients with indolent cutaneous T-cell lymphomas (CTCLs) and 34 patients with indolent cutaneous B-cell lymphomas (CBCLs) were included. The value of clinical examination, blood tests and imaging procedures for detection of recurrence or progression was assessed.
In patients with CTCL all but one disease recurrences were detected by clinical examination. Lymph node or organ involvement was detected by imaging procedures in seven patients, of whom all but one had recurrent or persistent CL lesions. In CBCL all recurrences were detected by clinical examination.
Patients with indolent CL confined to the skin should be followed primarily by clinical examination. However, in patients who are refractory to treatment regular screening of lymph nodes by ultrasound may enable earlier detection of disease recurrence or progression.
原发性皮肤淋巴瘤（CL）是一组起源于 B 或 T 淋巴细胞的异质性疾病。根据其临床行为，CL 分为惰性、中间型和侵袭性。惰性 CL 对治疗反应良好，但经常复发，导致长期随访。
评估惰性 CL 随访检查的结果。
我们回顾性分析了一家三级转诊中心的 CL 门诊患者队列。共纳入 75 例惰性皮肤 T 细胞淋巴瘤（CTCL）患者和 34 例惰性皮肤 B 细胞淋巴瘤（CBCL）患者。评估了临床检查、血液检查和影像学检查对复发或进展的检测价值。
在 CTCL 患者中，除 1 例外，所有疾病复发均通过临床检查发现。7 例患者的淋巴结或器官受累通过影像学检查发现，其中除 1 例外均有复发性或持续性 CL 病变。在 CBCL 患者中，所有复发均通过临床检查发现。
局限于皮肤的惰性 CL 患者应主要通过临床检查进行随访。然而，对于治疗抵抗的患者，定期进行超声检查以筛查淋巴结可能有助于更早发现疾病复发或进展。
