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Association of Hb New York with Hb E and α(0)-thalassemia in a Chinese woman identified by Sebia CapillaryS2 system.

作者信息

Li Dong-Zhi, Zhou Jian-Ying, Xie Xing-Mei, Liao Can

机构信息

Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China.

出版信息

Hemoglobin. 2012;36(2):157-60. doi: 10.3109/03630269.2012.658129. Epub 2012 Feb 22.

DOI:10.3109/03630269.2012.658129
PMID:22356116
Abstract

We describe a Chinese woman who was assumed to be heterozygous for both Hb E [β26(B8)Glu→Lys] and α(0)-thalassemia (α(0)-thal) by a high performance liquid chromatography (HPLC) method, but was later also shown to be a Hb New York [β113(G15)Val→Glu] heterozygote by the Sebia CapillaryS2 system. This study suggested that a single test is never sufficient to allow the correct diagnosis of an abnormal hemoglobin (Hb). We also emphasize the importance of a correct diagnosis of interactions between α- and β-thalassemias.

摘要

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